biostudies-literatureSherifali DTHeather M Arthur Population Health Research Institute/Hamilton Health SciencesCanadian Institutes of Health ResearchCIHR2181-2191https://www.ebi.ac.uk/biostudies/studies/S-EPMC12635883biostudies-literatureUnknown48(12)<h4>Background</h4>Evidence that type 2 diabetes can be reversed has been limited by the understanding and implementation of these interventions.<h4>Purpose</h4>We assessed the effect of nonsurgical randomized controlled trials (RCTs) on type 2 diabetes remission and characterized core components.<h4>Data sources</h4>We reviewed articles from MEDLINE and Embase (inception to April 2025).<h4>Study selection</h4>RCTs of multimodal pharmacological or nonpharmacological type 2 diabetes remission interventions for adults with type 2 diabetes were included.<h4>Data extraction</h4>Study characteristics and outcomes for clinical/population health, patient-reported, and adverse event were extracted.<h4>Data synthesis</h4>We performed a random-effects multilevel meta-analysis of studies, grouped basDiabetes careType 2 Diabetes Remission: A Systematic Review and Meta-analysis of Nonsurgical Randomized Controlled Trials.PMC12635883KM2-196997Racey MEAli MURoglich JGerstein HCRabi DKim JChouinor KEmond REwer MGreenway MKSherifali DTNerenberg KSherifali DDasgupta KIntegrated Knowledge Translation (iKT) Type 2 Diabetes Remission Advisory Team*Kastner MHonshort KMcKenna BMcInnes NLipscombe LLamb KMcQuire TRacey MGamble JMMcKelvey SBrown JFitzpatrick-Lewis DPunthakee ZAlliston PEChiavaroli LAlliston PMakarski JGerstein HfalseType 2 Diabetes Remission: A Systematic Review and Meta-analysis of Nonsurgical Randomized Controlled Trials.<h4>Background</h4>Evidence that type 2 diabetes can be reversed has been limited by the understanding and implementation of these interventions.<h4>Purpose</h4>We assessed the effect of nonsurgical randomized controlled trials (RCTs) on type 2 diabetes remission and characterized core components.<h4>Data sources</h4>We reviewed articles from MEDLINE and Embase (inception to April 2025).<h4>Study selection</h4>RCTs of multimodal pharmacological or nonpharmacological type 2 diabetes remission interventions for adults with type 2 diabetes were included.<h4>Data extraction</h4>Study characteristics and outcomes for clinical/population health, patient-reported, and adverse event were extracted.<h4>Data synthesis</h4>We performed a random-effects multilevel meta-analysis of studies, grouped bas2025-01-01T00:00:00Z2025 Dec2026-05-20T03:23:43.441Z2026-05-20T03:14:53.003ZS-EPMC126358834098232710.2337/dc25-0562