{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["17(46)"],"submitter":["Giannini N"],"pubmed_abstract":["Radiotherapy (RT) is a commonly employed treatment in oncological setting. Unfortunately, the therapeutic dose required for tumor control often induces significant side effects in normal tissues, leading to suboptimal outcomes and reduced patient quality of life. FLASH radiotherapy (FLASH-RT) is distinguished by its exceptionally high dose rates, surpassing 40 Gy/s. This advancement has emerged as a promising innovation in the field of cancer treatment. Indeed, FLASH-RT may reduce normal tissue toxicity compared to conventional radiotherapy (CONV-RT) while maintaining tumor control. Here, FLASH-RT and CONV-RT have been compared in an alternative embryonic model of pancreatic carcinoma, a cancer type with poor prognosis and limited therapeutic options. The chorioallantoic membrane models (C"],"journal":["ACS applied materials & interfaces"],"pagination":["63286-63295"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12635963"],"repository":["biostudies-literature"],"pubmed_title":["FLASH Radiotherapy Enhances the Therapeutic Ratio in an Embryonic In Vivo Model of Pancreatic Carcinoma."],"pmcid":["PMC12635963"],"pubmed_authors":["Pensavalle JH","Paiar F","Voliani V","Di Cocco F","Cavalieri A","Giannini N","Gadducci G","Scatena C","Puccini P","Menicagli M","Masturzo L","Sarogni P","Cioni D","Naccarato AG","Di Martino F","Aquaro GD","Gonnelli A","Celentano M","Frusca V"],"additional_accession":[]},"is_claimable":false,"name":"FLASH Radiotherapy Enhances the Therapeutic Ratio in an Embryonic In Vivo Model of Pancreatic Carcinoma.","description":"Radiotherapy (RT) is a commonly employed treatment in oncological setting. Unfortunately, the therapeutic dose required for tumor control often induces significant side effects in normal tissues, leading to suboptimal outcomes and reduced patient quality of life. FLASH radiotherapy (FLASH-RT) is distinguished by its exceptionally high dose rates, surpassing 40 Gy/s. This advancement has emerged as a promising innovation in the field of cancer treatment. Indeed, FLASH-RT may reduce normal tissue toxicity compared to conventional radiotherapy (CONV-RT) while maintaining tumor control. Here, FLASH-RT and CONV-RT have been compared in an alternative embryonic model of pancreatic carcinoma, a cancer type with poor prognosis and limited therapeutic options. The chorioallantoic membrane models (C","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-06T07:00:55.709Z","creation":"2026-06-06T03:06:16.354Z"},"accession":"S-EPMC12635963","cross_references":{"pubmed":["41202091"],"doi":["10.1021/acsami.5c19638"]}}