{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Zhang K"],"funding":["NHLBI NIH HHS"],"pubmed_abstract":["Lung size control and cell type specification are key unresolved issues. In this study, we have engineered mosaic patterns of Hippo signaling to reveal the developmental potential of SOX9<sup>+</sup> progenitors at the distal lung buds. Our results show that the distal SOX9<sup>+</sup> subdomain is sufficient to direct lung outgrowth through bifurcation, providing a mechanism for lung size control. Through single-cell analyses, we identify transitional cell states and candidates for promoting cell fates. Moreover, genetic analysis reveals that Hippo signaling induces distinct cell fates at different SOX9<sup>+</sup> subdomains to produce the conducting airways and the alveolar epithelium. These results provide the first map of the developmental paths of lung cells. Some of the developmenta"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2025.10.28.684989"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12636293"],"repository":["biostudies-literature"],"pubmed_title":["Hippo signaling differentially regulates distal progenitor subpopulations and their transitional states to construct the mammalian lungs."],"pmcid":["PMC12636293"],"funding_grant_id":["R01 HL157446"],"pubmed_authors":["Zhang K","Chuang PT","Zaher Y","Basak M","Wang SA","Aung T","Yao E"],"additional_accession":[]},"is_claimable":false,"name":"Hippo signaling differentially regulates distal progenitor subpopulations and their transitional states to construct the mammalian lungs.","description":"Lung size control and cell type specification are key unresolved issues. In this study, we have engineered mosaic patterns of Hippo signaling to reveal the developmental potential of SOX9<sup>+</sup> progenitors at the distal lung buds. Our results show that the distal SOX9<sup>+</sup> subdomain is sufficient to direct lung outgrowth through bifurcation, providing a mechanism for lung size control. Through single-cell analyses, we identify transitional cell states and candidates for promoting cell fates. Moreover, genetic analysis reveals that Hippo signaling induces distinct cell fates at different SOX9<sup>+</sup> subdomains to produce the conducting airways and the alveolar epithelium. These results provide the first map of the developmental paths of lung cells. Some of the developmenta","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-07-02T03:15:58.194Z","creation":"2026-07-02T03:08:54.291Z"},"accession":"S-EPMC12636293","cross_references":{"pubmed":["41278867"],"doi":["10.1101/2025.10.28.684989"]}}