{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Jiang A"],"funding":["NIMH NIH HHS","NINDS NIH HHS"],"pubmed_abstract":["CA1 place fields support spatial maps critical for memory, yet how bilateral CA3 inputs shape these maps during learning remains unclear. Using two-photon calcium imaging and optogenetic inhibition in head-fixed mice navigating a virtual track, we examined left and right CA3 projections to right CA1 (CA1<sub>R</sub>) as animals familiarized to a novel environment. CA1<sub>R</sub> maps were initially inaccurate but stabilized after ~10 laps, defining an early-phase of map refinement followed by a late-phase of stability. During the early-phase, right CA3 inputs predominantly drove refinement, whereas left CA3 inputs controlled stability later. These effects arose at the single-cell level, with right CA3 inputs driving high-amplitude, reliable fields early and left inputs supporting reliable fields later. Axonal recordings revealed a matching shift: right CA3 axons showed greater place-field activity and reliability early, whereas left CA3 axons became more reliable later. Thus, CA3 input dominance transitions from right to left, coordinating CA1<sub>R</sub> map refinement and stabilization."],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2025.10.26.684700"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12636601"],"repository":["biostudies-literature"],"pubmed_title":["Learning-Dependent Shift from Right to Left CA3 Input Dominance Shapes the Evolution of Right CA1 Spatial Maps."],"pmcid":["PMC12636601"],"funding_grant_id":["RF1 NS127123","R21 NS128822","DP2 NS111657","R01 MH136274"],"pubmed_authors":["GoodSmith D","Tortolani AF","Ramirez-Matias J","Sheffield MEJ","Jiang A"],"additional_accession":[]},"is_claimable":false,"name":"Learning-Dependent Shift from Right to Left CA3 Input Dominance Shapes the Evolution of Right CA1 Spatial Maps.","description":"CA1 place fields support spatial maps critical for memory, yet how bilateral CA3 inputs shape these maps during learning remains unclear. Using two-photon calcium imaging and optogenetic inhibition in head-fixed mice navigating a virtual track, we examined left and right CA3 projections to right CA1 (CA1<sub>R</sub>) as animals familiarized to a novel environment. CA1<sub>R</sub> maps were initially inaccurate but stabilized after ~10 laps, defining an early-phase of map refinement followed by a late-phase of stability. During the early-phase, right CA3 inputs predominantly drove refinement, whereas left CA3 inputs controlled stability later. These effects arose at the single-cell level, with right CA3 inputs driving high-amplitude, reliable fields early and left inputs supporting reliable fields later. Axonal recordings revealed a matching shift: right CA3 axons showed greater place-field activity and reliability early, whereas left CA3 axons became more reliable later. Thus, CA3 input dominance transitions from right to left, coordinating CA1<sub>R</sub> map refinement and stabilization.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-16T03:09:41.66Z","creation":"2026-06-16T03:06:23.081Z"},"accession":"S-EPMC12636601","cross_references":{"pubmed":["41279309"],"doi":["10.1101/2025.10.26.684700"]}}