{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(47)"],"submitter":["Contesse T"],"pubmed_abstract":["The lateral hypothalamic area (LHA) integrates external stimuli with internal states to drive the choice between competing innate or value-driven motivated behaviors. Here, we define a striosomal Tac1+/Tshz1+/Oprm1+ neuron subtype in the nucleus accumbens (ACB) that targets Esr1+ LHA neurons that project to the lateral habenula (LHb). Intersectional cell type-specific and input-output defined optogenetic activation of this ACB-LHA-LHb pathway can progressively induce a negative behavioral state that depends on Esr1+ LHA-LHb neural activity. We found that either activation of the D1+ ACB-LHA projection or inhibition of LHA-LHb neurons defined by ACB inputs can drive reward-independent compulsive-like behaviors that generalize across contexts. We found that these complex yet stereotyped beha"],"journal":["Science advances"],"pagination":["eadx9450"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12637280"],"repository":["biostudies-literature"],"pubmed_title":["A striosomal accumbens pathway drives stereotyped behavior through an aversive Esr1+ hypothalamic-habenula circuit."],"pmcid":["PMC12637280"],"pubmed_authors":["Jung F","Meletis K","Sandberg R","Bektash BY","Forastieri C","Skara V","Mantas I","Hahne S","Contestabile A","Calvigioni D","Nikolakopoulou I","Graziano M","Cao X","Giatrellis S","Contesse T","Carlen M","Rubino E"],"additional_accession":[]},"is_claimable":false,"name":"A striosomal accumbens pathway drives stereotyped behavior through an aversive Esr1+ hypothalamic-habenula circuit.","description":"The lateral hypothalamic area (LHA) integrates external stimuli with internal states to drive the choice between competing innate or value-driven motivated behaviors. Here, we define a striosomal Tac1+/Tshz1+/Oprm1+ neuron subtype in the nucleus accumbens (ACB) that targets Esr1+ LHA neurons that project to the lateral habenula (LHb). Intersectional cell type-specific and input-output defined optogenetic activation of this ACB-LHA-LHb pathway can progressively induce a negative behavioral state that depends on Esr1+ LHA-LHb neural activity. We found that either activation of the D1+ ACB-LHA projection or inhibition of LHA-LHb neurons defined by ACB inputs can drive reward-independent compulsive-like behaviors that generalize across contexts. We found that these complex yet stereotyped beha","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-05T16:51:26.735Z","creation":"2026-05-19T03:11:53.143Z"},"accession":"S-EPMC12637280","cross_references":{"pubmed":["41270158"],"doi":["10.1126/sciadv.adx9450"]}}