{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Peng Y"],"funding":["National institute of health","NIA NIH HHS","NIAMS NIH HHS","NIGMS NIH HHS"],"pubmed_abstract":["Resting collecting lymphatic vessels (cLVs) sense edema in distal joints and initiate contractions via unknown mechanisms. Rheumatoid arthritis (RA) patients have lymphatic drainage deficiencies from affected joints, and defects in the synovial lymphatic system exacerbate inflammatory-erosive arthritis in animal models. To understand this, we generated <i>Efhd1</i>-CreER<sup>T2</sup> and <i>Myoc</i>-CreER<sup>T2</sup> mice for cell-specific genetic gain and loss of function studies. These mice were crossed with tdTomato reporter (Ai9) mice, and studies showed selective tamoxifen-induced transgene expression in CD31<sup>-</sup>/CD34<sup>+</sup> telocyte-like cells in knee and ankle synovium, and in networks physically associated with mast cells proximal to popliteal lymphatic vessels (PLVs)"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2025.11.03.685859"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12637515"],"repository":["biostudies-literature"],"pubmed_title":["The Function of &lt;i&gt;Efhd1&lt;/i&gt; &lt;sup&gt;+&lt;/sup&gt; Telocytes in the Synovial Lymphatic System and Inflammatory-Erosive Arthritis."],"pmcid":["PMC12637515"],"funding_grant_id":["F30 AG069329 (HMK), T32GM007356 (HMK), R01AR063650, R01AG059775 (LX), R01AR069000 (CTR), R01AR056702 (EMS), and P30 AR069655 (EMS)","R01 AR069000","P30 AR069655","T32 GM007356","R01 AR056702","R01 AR063650","R01 AG059775","F30 AG076326"],"pubmed_authors":["Lydon S","Peng Y","Xing L","Schwarz EM","Ritchlin CT","de Mesy Bentley KL","Mark Kenney H","Korman BD","Kobryn A"],"additional_accession":[]},"is_claimable":false,"name":"The Function of &lt;i&gt;Efhd1&lt;/i&gt; &lt;sup&gt;+&lt;/sup&gt; Telocytes in the Synovial Lymphatic System and Inflammatory-Erosive Arthritis.","description":"Resting collecting lymphatic vessels (cLVs) sense edema in distal joints and initiate contractions via unknown mechanisms. Rheumatoid arthritis (RA) patients have lymphatic drainage deficiencies from affected joints, and defects in the synovial lymphatic system exacerbate inflammatory-erosive arthritis in animal models. To understand this, we generated <i>Efhd1</i>-CreER<sup>T2</sup> and <i>Myoc</i>-CreER<sup>T2</sup> mice for cell-specific genetic gain and loss of function studies. These mice were crossed with tdTomato reporter (Ai9) mice, and studies showed selective tamoxifen-induced transgene expression in CD31<sup>-</sup>/CD34<sup>+</sup> telocyte-like cells in knee and ankle synovium, and in networks physically associated with mast cells proximal to popliteal lymphatic vessels (PLVs)","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-06T03:16:14.967Z","creation":"2026-07-06T03:09:01.749Z"},"accession":"S-EPMC12637515","cross_references":{"pubmed":["41279427"],"doi":["10.1101/2025.11.03.685859"]}}