{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Fernandez Pujol C"],"funding":["NCATS NIH HHS","NINDS NIH HHS"],"pubmed_abstract":["The mismatch negativity, or MMN, is a ubiquitous evoked brain response elicited by any discriminable change of an otherwise regular stimulus sequence. Despite its potential clinical relevance - the MMN is known to be affected by brain state, lesions, and neurologic/psychiatric disorders - and a growing body of animal work, the underlying neurophysiology of the MMN is not well understood. This hinders translation of circuit-level animal findings and mitigates the utility of the MMN as a neurologic/psychiatric biomarker. Here, we used biophysical modeling to examine the neurophysiological basis of the MMN as measured in a canonical auditory oddball paradigm with frequency deviants (i.e., tones whose frequency was shifted slightly with respect to standard tones). The response to standards was"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2025.11.08.687373"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12637574"],"repository":["biostudies-literature"],"pubmed_title":["Neurophysiology of mismatch negativity generation: a biophysical modeling study."],"pmcid":["PMC12637574"],"funding_grant_id":["U24 NS129945","UL1 TR002736"],"pubmed_authors":["Dykstra AR","Bruce J","Fernandez Pujol C","Thorpe RV","Jones SR"],"additional_accession":[]},"is_claimable":false,"name":"Neurophysiology of mismatch negativity generation: a biophysical modeling study.","description":"The mismatch negativity, or MMN, is a ubiquitous evoked brain response elicited by any discriminable change of an otherwise regular stimulus sequence. Despite its potential clinical relevance - the MMN is known to be affected by brain state, lesions, and neurologic/psychiatric disorders - and a growing body of animal work, the underlying neurophysiology of the MMN is not well understood. This hinders translation of circuit-level animal findings and mitigates the utility of the MMN as a neurologic/psychiatric biomarker. Here, we used biophysical modeling to examine the neurophysiological basis of the MMN as measured in a canonical auditory oddball paradigm with frequency deviants (i.e., tones whose frequency was shifted slightly with respect to standard tones). The response to standards was","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-10T03:12:59.047Z","creation":"2026-06-10T03:07:43.298Z"},"accession":"S-EPMC12637574","cross_references":{"pubmed":["41279217"],"doi":["10.1101/2025.11.08.687373"]}}