biostudies-literatureUnknownDavies BEIntramural NIH HHSEuropean Research CouncilBiotechnology and Biological Sciences Research Council<h4>Background</h4>The polychaete <i>Capitella teleta</i> is a commonly used annelid for studies in evolutionary developmental biology, comparative genomics, conservation, and ecotoxicology. Over a decade ago, it was the first polychaete to have its genome sequenced and assembled, contributing to pioneering studies that transformed our understanding of animal genomes and their evolution. However, this early resource is now outdated compared to current genome sequencing standards, limiting the use of modern functional genomic tools that could further our understanding of numerous biological processes.<h4>Results</h4>We combine long-read and short-read sequencing with Hi-C chromatin conformation capture data to assemble the chromosome-level nuclear and mitochondrial genomes of the laboratorybioRxiv : the preprint server for biology2025.10.31.685816https://www.ebi.ac.uk/biostudies/studies/S-EPMC12637686biostudies-literatureA chromosome-level assembly and functional genomic resources for the model annelid &lt;i&gt;Capitella teleta&lt;/i&gt;.PMC12637686BB/Y004221/1801669ZIA HG000140BB/T008709/1Frankish TLiang YSeaver ECDavies BEZhang SGonzalez PTravis Moreland RMontagne JDonnellan RDGuynes KSur AMeyer NPMartin-Duran JMCarrillo-Baltodano AMWolfsberg TGBaxevanis ADWei JSingh SfalseA chromosome-level assembly and functional genomic resources for the model annelid &lt;i&gt;Capitella teleta&lt;/i&gt;.<h4>Background</h4>The polychaete <i>Capitella teleta</i> is a commonly used annelid for studies in evolutionary developmental biology, comparative genomics, conservation, and ecotoxicology. Over a decade ago, it was the first polychaete to have its genome sequenced and assembled, contributing to pioneering studies that transformed our understanding of animal genomes and their evolution. However, this early resource is now outdated compared to current genome sequencing standards, limiting the use of modern functional genomic tools that could further our understanding of numerous biological processes.<h4>Results</h4>We combine long-read and short-read sequencing with Hi-C chromatin conformation capture data to assemble the chromosome-level nuclear and mitochondrial genomes of the laboratory2025-01-01T00:00:00Z2025 Nov2026-06-02T03:11:00.522Z2026-06-02T03:09:04.196ZS-EPMC126376864127911210.1101/2025.10.31.685816