{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Takemura A"],"funding":["Yamaha Motor Co Ltd","Japan Society for the Promotion of Science"],"pagination":["102341"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12639397"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["44"],"pubmed_abstract":["Mild hyperbaric oxygen (MHO) attenuates the muscle atrophy caused by muscle disuse. Training cessation results in the partial or complete loss of training-induced adaptations, including mitochondrial enzyme activities. The present study aimed to determine whether exposure to MHO after running training attenuated negative adaptation induced by detraining. We allocated eight-week-old mice into training (Tr), detraining after the training period (DeTr), and detraining + mild hyperbaric oxygen (DeTr + MHO, 1.3 atm absolute with 38 % oxygen) groups. Mice underwent voluntary wheel running for four weeks, followed by a two-week detraining period under normal or MHO conditions. The soleus muscle weight (mg/g BW) decreased by approximately 30 % in the DeTr and DeTr + MHO groups compared to the Tr g"],"journal":["Biochemistry and biophysics reports"],"pubmed_title":["Mild hyperbaric oxygen does not attenuate mitochondrial decrease induced by detraining in mice."],"pmcid":["PMC12639397"],"funding_grant_id":["24K20722"],"pubmed_authors":["Egawa T","Uemichi K","Fujita S","Hayashi T","Iyama R","Oba M","Takemura A","Zhao H"],"additional_accession":[]},"is_claimable":false,"name":"Mild hyperbaric oxygen does not attenuate mitochondrial decrease induced by detraining in mice.","description":"Mild hyperbaric oxygen (MHO) attenuates the muscle atrophy caused by muscle disuse. Training cessation results in the partial or complete loss of training-induced adaptations, including mitochondrial enzyme activities. The present study aimed to determine whether exposure to MHO after running training attenuated negative adaptation induced by detraining. We allocated eight-week-old mice into training (Tr), detraining after the training period (DeTr), and detraining + mild hyperbaric oxygen (DeTr + MHO, 1.3 atm absolute with 38 % oxygen) groups. Mice underwent voluntary wheel running for four weeks, followed by a two-week detraining period under normal or MHO conditions. The soleus muscle weight (mg/g BW) decreased by approximately 30 % in the DeTr and DeTr + MHO groups compared to the Tr g","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-01T03:20:18.939Z","creation":"2026-06-01T03:11:03.622Z"},"accession":"S-EPMC12639397","cross_references":{"pubmed":["41282542"],"doi":["10.1016/j.bbrep.2025.102341"]}}