biostudies-literatureUnknown19(10)Bouwknegt DG<h4>Background and aims</h4>Inflammatory bowel disease (IBD) often coincides with pregnancy, and disease activity during pregnancy increases the risk of adverse outcomes. We aimed to determine how disease course before conception influences relapse risk during pregnancy, adjusting for established risk factors.<h4>Methods</h4>In this multicenter, retrospective cohort study, we included adult women with IBD who were pregnant during treatment at one of three university hospitals between 2017 and 2022. Using generalized estimating equations, we evaluated associations between relapse during pregnancy and pre-conceptional flares, categorized into three time intervals. Analyses were adjusted for phenotype, disease duration, surgical history, biologic use, smoking, and assisted reproduction. InterJournal of Crohn's & colitisjjaf176https://www.ebi.ac.uk/biostudies/studies/S-EPMC12640223biostudies-literatureHow long is long enough? Timing of pre-conceptional remission predicts relapse risk during pregnancy in IBD.PMC12640223Hoekstra Bvan Dop WPierik Mvan der Woude CJde Vries ABodelier ALowenberg Mvan der Marel Sde Jonge VDerikx LVoorneveld PBouwknegt DGMares WNissen LHorjus COostenburg LDuijvestein MFesten NTauber TJansen Jvan der Meulen Avan Dop WAvan der Wouden EJMujagic ZMensink Pvan Es BFidder HRomkens TDonker HCGoetgebuer RMahmmod NVisschedijk MCSmeets XDutch Initiative on Crohn and Colitis (ICC)Jharap BGroen HWest Rvan der Voorn MDijkstra Gvan Schaik FVisschedijk MfalseHow long is long enough? Timing of pre-conceptional remission predicts relapse risk during pregnancy in IBD.<h4>Background and aims</h4>Inflammatory bowel disease (IBD) often coincides with pregnancy, and disease activity during pregnancy increases the risk of adverse outcomes. We aimed to determine how disease course before conception influences relapse risk during pregnancy, adjusting for established risk factors.<h4>Methods</h4>In this multicenter, retrospective cohort study, we included adult women with IBD who were pregnant during treatment at one of three university hospitals between 2017 and 2022. Using generalized estimating equations, we evaluated associations between relapse during pregnancy and pre-conceptional flares, categorized into three time intervals. Analyses were adjusted for phenotype, disease duration, surgical history, biologic use, smoking, and assisted reproduction. Inter2025-01-01T00:00:00Z2025 Nov2026-05-21T03:16:54.736Z2026-05-21T03:11:16.406ZS-EPMC126402234108174710.1093/ecco-jcc/jjaf176