{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Galasso J"],"funding":["NIMH NIH HHS","NHGRI NIH HHS"],"pubmed_abstract":["The emergence of multiomic single-cell Hi-C methods, which simultaneously profile chromatin conformation and other modalities such as gene expression or DNA methylation, creates tremendous opportunities for studying the genome's structure-function relationships. Existing tools for processing multiomic single-cell Hi-C datasets have certain limitations for downstream bioinformatics analysis. We present map3C, a software tool designed to address these limitations. We demonstrate that map3C improves the quality of multiomic single-cell Hi-C data for analysis and its utility for identifying structural variant locations in the genome."],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2025.10.10.681728"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12640563"],"repository":["biostudies-literature"],"pubmed_title":["map3C: a computational tool for processing multiomic single-cell Hi-C data."],"pmcid":["PMC12640563"],"funding_grant_id":["T32 HG002536","U01 HG012079","R01 MH125252","UM1 HG011593","U01 MH130995"],"pubmed_authors":["Galasso J","Ernst J","Wang Y","Luo C","Alber F"],"additional_accession":[]},"is_claimable":false,"name":"map3C: a computational tool for processing multiomic single-cell Hi-C data.","description":"The emergence of multiomic single-cell Hi-C methods, which simultaneously profile chromatin conformation and other modalities such as gene expression or DNA methylation, creates tremendous opportunities for studying the genome's structure-function relationships. Existing tools for processing multiomic single-cell Hi-C datasets have certain limitations for downstream bioinformatics analysis. We present map3C, a software tool designed to address these limitations. We demonstrate that map3C improves the quality of multiomic single-cell Hi-C data for analysis and its utility for identifying structural variant locations in the genome.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-05-31T03:10:00.072Z","creation":"2026-05-31T03:07:31.735Z"},"accession":"S-EPMC12640563","cross_references":{"pubmed":["41287777"],"doi":["10.1101/2025.10.10.681728"]}}