{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Keneni DA"],"funding":["South African National Research Foundation","NRF African Coelacanth Ecosystem Programme","German Academic Exchange Service","Deutscher Akademischer Austauschdienst France","South African Medical Research Council","German Academic Exchange Service France","DAAD"],"pagination":["e202500392"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12640659"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(22)"],"pubmed_abstract":["Marine sponges of the genus Oceanapia are prolific producers of bioactive secondary metabolites. Four known bifunctional sphingolipids are isolated: isorhizochalin (1), rhizochalin (2), rhizochalin C (3), and oceanapiside (4) from Oceanapia ramsayi sponges. These compounds are derivatized to form aglycones (1b-4b), perbenzoates (1c-4c), and bis-oxazoline (2e). The compounds and their derivatives are investigated for their cytotoxicity against three breast cancer cell lines (HCC70, MDA-MB-231, MCF7). All four sphingolipids are cytotoxic with significant selectivity indices (SI) for the three breast cancer cells. Compound 1 has high selectivity against the HCC70 cell line, 4 against the MDA-MB-231 cells, and aglycon 4b against both the MDA-MB-231 and MCF7 cell lines, respectively, demonstrat"],"journal":["ChemMedChem"],"pubmed_title":["Dual Biological Potential: Anticancer and Antibacterial Activities of Bis-α, ω-Bifunctional Sphingolipids from the Marine Sponge Oceanapia ramsayi."],"pmcid":["PMC12640659"],"funding_grant_id":["91700877","AMR DD96815","GUN: 97967","91758998","GUN: 87583"],"pubmed_authors":["Swart T","Davison C","de la Mare JA","Dorrington RA","Kalinski JJ","Keneni DA","Isaacs M","Njanje I"],"additional_accession":[]},"is_claimable":false,"name":"Dual Biological Potential: Anticancer and Antibacterial Activities of Bis-α, ω-Bifunctional Sphingolipids from the Marine Sponge Oceanapia ramsayi.","description":"Marine sponges of the genus Oceanapia are prolific producers of bioactive secondary metabolites. Four known bifunctional sphingolipids are isolated: isorhizochalin (1), rhizochalin (2), rhizochalin C (3), and oceanapiside (4) from Oceanapia ramsayi sponges. These compounds are derivatized to form aglycones (1b-4b), perbenzoates (1c-4c), and bis-oxazoline (2e). The compounds and their derivatives are investigated for their cytotoxicity against three breast cancer cell lines (HCC70, MDA-MB-231, MCF7). All four sphingolipids are cytotoxic with significant selectivity indices (SI) for the three breast cancer cells. Compound 1 has high selectivity against the HCC70 cell line, 4 against the MDA-MB-231 cells, and aglycon 4b against both the MDA-MB-231 and MCF7 cell lines, respectively, demonstrat","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-05T18:48:37.495Z","creation":"2026-05-20T03:13:14.071Z"},"accession":"S-EPMC12640659","cross_references":{"pubmed":["41183286"],"doi":["10.1002/cmdc.202500392"]}}