{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Diachenko M"],"funding":["European Union Joint Programme – Neurodegenerative Disease Research","Dutch National Epilepsy Foundation","Netherlands Organization for Health and Development","REBALANCE","ZonMw"],"pagination":["fcaf443"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12641122"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(6)"],"pubmed_abstract":["Early stages of Alzheimer's disease are marked by brain hyperexcitability, evidenced by subclinical epileptiform features suggesting an excitation-inhibition imbalance. Clinically translatable biomarkers for early detection of excitation-inhibition changes at the network level, however, are lacking. We investigated the functional excitation-inhibition ratio, theta-gamma phase-amplitude coupling and epileptiform features in hippocampal and cortical local field potentials recorded weekly in freely behaving male APPswe/PS1dE9 (APP/PS1) mice (<i>n</i> = 10) and wild-type controls (<i>n</i> = 10) between 3 and up to and including 11 months of age. APP/PS1 mice exhibited a shift towards increased excitation, reflected in the elevated functional excitation-inhibition ratio emerging most prominently in the hippocampus at 6 months. Additionally, elevated population spiking activity and age-related impairments in theta-gamma phase-amplitude coupling were observed in the local field potentials of APP/PS1 mice in both the hippocampus and the cortex. Importantly, the functional excitation-inhibition ratio correlated positively with elevated population spiking activity in both brain regions in APP/PS1 mice. Our findings highlight the functional excitation-inhibition ratio as a promising biomarker of hippocampal and cortical network disinhibition and hyperexcitability in APP/PS1 mice, with potential value as an early disease marker in Alzheimer's disease."],"journal":["Brain communications"],"pubmed_title":["Hippocampal and cortical activities reflect early hyperexcitability in an Alzheimer's mouse model."],"pmcid":["PMC12641122"],"funding_grant_id":["2022-10","10510062210003","2019/01724/ZONMW"],"pubmed_authors":["Tolner EA","Krivoshein G","Diachenko M","van Kesteren RE","Linkenkaer-Hansen K","Mansvelder HD","van den Maagdenberg AMJM"],"additional_accession":[]},"is_claimable":false,"name":"Hippocampal and cortical activities reflect early hyperexcitability in an Alzheimer's mouse model.","description":"Early stages of Alzheimer's disease are marked by brain hyperexcitability, evidenced by subclinical epileptiform features suggesting an excitation-inhibition imbalance. Clinically translatable biomarkers for early detection of excitation-inhibition changes at the network level, however, are lacking. We investigated the functional excitation-inhibition ratio, theta-gamma phase-amplitude coupling and epileptiform features in hippocampal and cortical local field potentials recorded weekly in freely behaving male APPswe/PS1dE9 (APP/PS1) mice (<i>n</i> = 10) and wild-type controls (<i>n</i> = 10) between 3 and up to and including 11 months of age. APP/PS1 mice exhibited a shift towards increased excitation, reflected in the elevated functional excitation-inhibition ratio emerging most prominently in the hippocampus at 6 months. Additionally, elevated population spiking activity and age-related impairments in theta-gamma phase-amplitude coupling were observed in the local field potentials of APP/PS1 mice in both the hippocampus and the cortex. Importantly, the functional excitation-inhibition ratio correlated positively with elevated population spiking activity in both brain regions in APP/PS1 mice. Our findings highlight the functional excitation-inhibition ratio as a promising biomarker of hippocampal and cortical network disinhibition and hyperexcitability in APP/PS1 mice, with potential value as an early disease marker in Alzheimer's disease.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-05-31T03:15:03.424Z","creation":"2026-05-31T03:10:06.088Z"},"accession":"S-EPMC12641122","cross_references":{"pubmed":["41293234"],"doi":["10.1093/braincomms/fcaf443"]}}