{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8"],"submitter":["Kanetkar S"],"pubmed_abstract":["Late-life depression is associated with an increased risk of developing dementia related to Alzheimer's disease, yet the mechanism underlying this relationship remains poorly understood. This study investigated the association of late-life depressive symptoms (LLDS) with brain amyloid deposition by PET. 334 dementia-free individuals from the Atherosclerosis Risk in Communities Study had Florbetapir-PET scans in late-life (ages 67-89). Elevated global and regional brain amyloid deposition was defined as a Florbetapir standardized uptake value ratio (SUVR) > 1.2. <i>LLDS</i> was assessed using the 11-item Center for Epidemiological Studies Depression Scale (CES-D) and defined as late-life CES-D ≥ 9. Several secondary depression measures (e.g., antidepressant use) were also explored. Stratifi"],"journal":["Aging brain"],"pagination":["100152"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12642136"],"repository":["biostudies-literature"],"pubmed_title":["The association of late-life depressive symptoms with brain amyloid-β deposition: the ARIC-PET study."],"pmcid":["PMC12642136"],"pubmed_authors":["Kanetkar S","Wong DF","Gottesman RF","Egle MT","Morrill VN","Walker KA"],"additional_accession":[]},"is_claimable":false,"name":"The association of late-life depressive symptoms with brain amyloid-β deposition: the ARIC-PET study.","description":"Late-life depression is associated with an increased risk of developing dementia related to Alzheimer's disease, yet the mechanism underlying this relationship remains poorly understood. This study investigated the association of late-life depressive symptoms (LLDS) with brain amyloid deposition by PET. 334 dementia-free individuals from the Atherosclerosis Risk in Communities Study had Florbetapir-PET scans in late-life (ages 67-89). Elevated global and regional brain amyloid deposition was defined as a Florbetapir standardized uptake value ratio (SUVR) > 1.2. <i>LLDS</i> was assessed using the 11-item Center for Epidemiological Studies Depression Scale (CES-D) and defined as late-life CES-D ≥ 9. Several secondary depression measures (e.g., antidepressant use) were also explored. Stratifi","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-05T18:38:14.155Z","creation":"2026-05-20T03:13:52.109Z"},"accession":"S-EPMC12642136","cross_references":{"pubmed":["41293752"],"doi":["10.1016/j.nbas.2025.100152"]}}