{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Pereira DT"],"pubmed_abstract":["<i>Passiflora setacea</i> seed oil is a natural source of bioactive unsaturated fatty acids, notably linoleic acid (ω-6) and oleic acid (ω-9), with promising antioxidant and anti-inflammatory potential for dermatological applications. However, its direct use is limited by poor physicochemical and organoleptic properties. This study aimed to develop and optimize a topical microemulsion (ME) system incorporating <i>P. setacea</i> seed oil using quality by design principles to address formulation challenges. The oil was extracted via Soxhlet and characterized by gas chromatography-mass spectrometry and thermal analysis. A full factorial design, followed by a Box-Behnken design, was employed to optimize the formulation based on critical quality attributes and the defined quality target product"],"journal":["Beilstein journal of nanotechnology"],"pagination":["2116-2131"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12642947"],"repository":["biostudies-literature"],"pubmed_title":["Quality by design optimization of microemulsions for topical delivery of &lt;i&gt;Passiflora setacea&lt;/i&gt; seed oil."],"pmcid":["PMC12642947"],"pubmed_authors":["Aragao CFS","de Souza ML","de Araujo GRS","Sapin-Minet A","Porto DL","Costa AM","Oliveira WN","Alencar EN","Pereira DT","Freire DT","Dourado D","Egito EST"],"additional_accession":[]},"is_claimable":false,"name":"Quality by design optimization of microemulsions for topical delivery of &lt;i&gt;Passiflora setacea&lt;/i&gt; seed oil.","description":"<i>Passiflora setacea</i> seed oil is a natural source of bioactive unsaturated fatty acids, notably linoleic acid (ω-6) and oleic acid (ω-9), with promising antioxidant and anti-inflammatory potential for dermatological applications. However, its direct use is limited by poor physicochemical and organoleptic properties. This study aimed to develop and optimize a topical microemulsion (ME) system incorporating <i>P. setacea</i> seed oil using quality by design principles to address formulation challenges. The oil was extracted via Soxhlet and characterized by gas chromatography-mass spectrometry and thermal analysis. A full factorial design, followed by a Box-Behnken design, was employed to optimize the formulation based on critical quality attributes and the defined quality target product","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-06T06:50:40.615Z","creation":"2026-06-06T03:06:48.367Z"},"accession":"S-EPMC12642947","cross_references":{"pubmed":["41293449"],"doi":["10.3762/bjnano.16.146"]}}