{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zheng Z"],"funding":["Guangzhou National Laboratory"],"pagination":["e0336479"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12643299"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(11)"],"pubmed_abstract":["Hydrated electrons (eaq-) are widely studied in pollutant degradation owing to their high reducing power. Recent studies indicate that transiently generated eaq- during radiotherapy can enhance chemotherapeutic antitumor effects via reduction activity. However, biomedical applications remain limited because conventional methods generate eaq- in situ and are short-lived, precluding storage. In this study, we present a storable electromagnetic base liquid (EBL), reference-linked to prior preparation work, and analyze its physicochemical and organism-level effects. The EBL showed strong alkalinity (pH 13.08), low oxidation-reduction potential (ORP 47.1 mV), and a total antioxidant capacity of 1.6 mM Trolox equivalents antioxidant capacity. Using a larva zebrafish (Danio rerio) digital phenotyping platform, we identified a non-adverse concentration and generated unbiased predictions clustering EBL with antitumor, uric acid-lowering, and hypoglycemic drugs. These findings motivate further biological investigation of EBL's biomedical potential and provide a basis for subsequent validation."],"journal":["PloS one"],"pubmed_title":["New potentials in biomedical application of hydrated electrons: A functional and biomedical effects study of an electromagnetic base liquid containing hydrated electrons."],"pmcid":["PMC12643299"],"funding_grant_id":["GZNL2025C01009"],"pubmed_authors":["Zheng Z","Li X","Ran F","Zhang Y","Liang L","Zhang L","Bi L"],"additional_accession":[]},"is_claimable":false,"name":"New potentials in biomedical application of hydrated electrons: A functional and biomedical effects study of an electromagnetic base liquid containing hydrated electrons.","description":"Hydrated electrons (eaq-) are widely studied in pollutant degradation owing to their high reducing power. Recent studies indicate that transiently generated eaq- during radiotherapy can enhance chemotherapeutic antitumor effects via reduction activity. However, biomedical applications remain limited because conventional methods generate eaq- in situ and are short-lived, precluding storage. In this study, we present a storable electromagnetic base liquid (EBL), reference-linked to prior preparation work, and analyze its physicochemical and organism-level effects. The EBL showed strong alkalinity (pH 13.08), low oxidation-reduction potential (ORP 47.1 mV), and a total antioxidant capacity of 1.6 mM Trolox equivalents antioxidant capacity. Using a larva zebrafish (Danio rerio) digital phenotyping platform, we identified a non-adverse concentration and generated unbiased predictions clustering EBL with antitumor, uric acid-lowering, and hypoglycemic drugs. These findings motivate further biological investigation of EBL's biomedical potential and provide a basis for subsequent validation.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-06T03:16:12.009Z","creation":"2026-06-06T03:06:57.565Z"},"accession":"S-EPMC12643299","cross_references":{"pubmed":["41284675"],"doi":["10.1371/journal.pone.0336479"]}}