biostudies-literatureUnknown30(6)Goswami C<h4>Background</h4>Inflammation and malignancy studies in choledochal cystic malformations (CDC) are scarce. This research explores the role of inflammation, bile composition, and markers like cyclooxygenase-2 (COX-2), phosphorylated ribosomal protein S6 (PS6), matrix metallopeptidase-9 (MMP9), and mammalian target of rapamycin (mTOR) in CDC.<h4>Materials and methods</h4>This is a cross-sectional observational study. The study was conducted between January 2021 and December 2023. Bile samples from children being operated for CDC were collected and analyzed for biochemical and enzymatic constituents, while excised specimens underwent histopathological and immunohistochemistry (IHC) COX-2, mTOR, PS6, and MMP9. Statistical analysis evaluated data relationships, including descriptive statisticJournal of Indian Association of Pediatric Surgeons750-756https://www.ebi.ac.uk/biostudies/studies/S-EPMC12643371biostudies-literatureExploring the Correlation between Immunohistochemical Findings and Bile Constituents in Choledochal Malformation Specimens.PMC12643371Goswami CVerma AKakkar APrakash SAgarwala SYadav RfalseExploring the Correlation between Immunohistochemical Findings and Bile Constituents in Choledochal Malformation Specimens.<h4>Background</h4>Inflammation and malignancy studies in choledochal cystic malformations (CDC) are scarce. This research explores the role of inflammation, bile composition, and markers like cyclooxygenase-2 (COX-2), phosphorylated ribosomal protein S6 (PS6), matrix metallopeptidase-9 (MMP9), and mammalian target of rapamycin (mTOR) in CDC.<h4>Materials and methods</h4>This is a cross-sectional observational study. The study was conducted between January 2021 and December 2023. Bile samples from children being operated for CDC were collected and analyzed for biochemical and enzymatic constituents, while excised specimens underwent histopathological and immunohistochemistry (IHC) COX-2, mTOR, PS6, and MMP9. Statistical analysis evaluated data relationships, including descriptive statistic2025-01-01T00:00:00Z2025 Nov-Dec2026-06-06T03:14:29.497Z2026-06-06T03:06:33.81ZS-EPMC126433714129351210.4103/jiaps.jiaps_111_25