biostudies-literatureCabello Fernandez CBelgian Health Care Knowledge Centre1455-1472https://www.ebi.ac.uk/biostudies/studies/S-EPMC12644064biostudies-literatureUnknown40(8)<h4>Objective</h4>A subset of COVID-19 patients continues to experience cognitive difficulties 24 months post-infection. The factors driving these symptoms are complex, and the underlying pathophysiology is unclear. This study aimed to characterize individuals with Long COVID reporting cognitive issues.<h4>Method</h4>One hundred twenty-three patients underwent a comprehensive neuropsychological evaluation resulting from the baseline of an RCT study (COVCOG), along with questionnaires assessing cognitive complaints, fatigue, sleep difficulties, quality of life, psychological distress, and impact on daily activities. Latent Profile Analyses on cognitive scores were conducted to investigate the presence of different patient profiles. Robust analyses of variance and Pearson's chi-square examinArchives of clinical neuropsychology : the official journal of the National Academy of NeuropsychologistsProfiles of Individuals With Long COVID Reporting Persistent Cognitive Complaints.PMC12644064LCOV21-1303Willems SDelrue GLesoinne ACabello Fernandez CCollette FSlama HDupuis GFery PDidone VfalseProfiles of Individuals With Long COVID Reporting Persistent Cognitive Complaints.<h4>Objective</h4>A subset of COVID-19 patients continues to experience cognitive difficulties 24 months post-infection. The factors driving these symptoms are complex, and the underlying pathophysiology is unclear. This study aimed to characterize individuals with Long COVID reporting cognitive issues.<h4>Method</h4>One hundred twenty-three patients underwent a comprehensive neuropsychological evaluation resulting from the baseline of an RCT study (COVCOG), along with questionnaires assessing cognitive complaints, fatigue, sleep difficulties, quality of life, psychological distress, and impact on daily activities. Latent Profile Analyses on cognitive scores were conducted to investigate the presence of different patient profiles. Robust analyses of variance and Pearson's chi-square examin2025-01-01T00:00:00Z2025 Nov2026-07-15T12:04:27.176Z2026-07-04T03:12:52.889ZS-EPMC126440644064560810.1093/arclin/acaf064