{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Budkina A"],"pubmed_abstract":["<h4>Background</h4>CHASERR, a conserved long non-coding RNA located upstream of CHD2, transcriptionally represses CHD2 in <i>cis</i>. Both genes are highly expressed in lymphocytes, suggesting roles in immune regulation, though their functions remain undefined.<h4>Results</h4>We identified elevated expression of CHASERR and CHD2 in naïve and regulatory T cells through analysis of single-cell and bulk RNA-seq datasets. Both their promoters are bound by FOXP3, the key regulator of Treg cells, and FOXP1, the key regulator of naïve T cell quiescence. Expression dynamics during early T cell activation revealed that a decline in CHASERR precedes a transient increase in CHD2. Correlation analysis linked CHASERR/CHD2 expression to quiescence-associated genes, suggesting a role in maintaining T cel"],"journal":["Frontiers in immunology"],"pagination":["1652359"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12644095"],"repository":["biostudies-literature"],"pubmed_title":["CHASERR-CHD2 dynamics in T cell quiescence and its modulation by cyclosporine."],"pmcid":["PMC12644095"],"pubmed_authors":["Loguinova MY","Sergeev NA","Marakulina D","Budkina A","Zubritskiy A","Medvedeva YA"],"additional_accession":[]},"is_claimable":false,"name":"CHASERR-CHD2 dynamics in T cell quiescence and its modulation by cyclosporine.","description":"<h4>Background</h4>CHASERR, a conserved long non-coding RNA located upstream of CHD2, transcriptionally represses CHD2 in <i>cis</i>. Both genes are highly expressed in lymphocytes, suggesting roles in immune regulation, though their functions remain undefined.<h4>Results</h4>We identified elevated expression of CHASERR and CHD2 in naïve and regulatory T cells through analysis of single-cell and bulk RNA-seq datasets. Both their promoters are bound by FOXP3, the key regulator of Treg cells, and FOXP1, the key regulator of naïve T cell quiescence. Expression dynamics during early T cell activation revealed that a decline in CHASERR precedes a transient increase in CHD2. Correlation analysis linked CHASERR/CHD2 expression to quiescence-associated genes, suggesting a role in maintaining T cel","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-05T18:00:13.931Z","creation":"2026-05-20T03:09:33.375Z"},"accession":"S-EPMC12644095","cross_references":{"pubmed":["41306969"],"doi":["10.3389/fimmu.2025.1652359"]}}