{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kang M"],"funding":["Ministry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology)"],"pagination":["857"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12644464"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["Podocytopathy is an emerging global health concern characterized by the injury of podocytes through various direct or indirect mechanisms. Recent research has highlighted a potential link between podocyte loss and various programmed cell death pathways, while the precise mechanisms of podocyte injury remain ambiguous. We conducted single-nucleus RNA sequencing (snRNA-seq) on kidney tissues from adriamycin-induced nephropathy (AN) mice (BALB/c, male) and renal biopsy samples from patients with different types of podocytopathy, such as focal segmental glomerulosclerosis (FSGS), minimal change disease (MCD) and obesity-related glomerulopathy (ORG). We found podocytes in diseased groups exhibited elevated ferroptosis scores based on the gene module score of programmed cell death pathways. Targ"],"journal":["Cell death & disease"],"pubmed_title":["Elovl7 sensitizes podocytes to ferroptosis in podocytopathy by elongating polyunsaturated fatty acids."],"pmcid":["PMC12644464"],"funding_grant_id":["2022YFC2505400"],"pubmed_authors":["Zhou L","Wu J","Yan P","Zhan X","Qing J","Li Q","Zhao Y","Li M","Mao J","Lu M","Wen J","Zhu J","Wei R","Huang X","Kang M","Bai L","Wang X","Liu F"],"additional_accession":[]},"is_claimable":false,"name":"Elovl7 sensitizes podocytes to ferroptosis in podocytopathy by elongating polyunsaturated fatty acids.","description":"Podocytopathy is an emerging global health concern characterized by the injury of podocytes through various direct or indirect mechanisms. Recent research has highlighted a potential link between podocyte loss and various programmed cell death pathways, while the precise mechanisms of podocyte injury remain ambiguous. We conducted single-nucleus RNA sequencing (snRNA-seq) on kidney tissues from adriamycin-induced nephropathy (AN) mice (BALB/c, male) and renal biopsy samples from patients with different types of podocytopathy, such as focal segmental glomerulosclerosis (FSGS), minimal change disease (MCD) and obesity-related glomerulopathy (ORG). We found podocytes in diseased groups exhibited elevated ferroptosis scores based on the gene module score of programmed cell death pathways. Targ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-05T19:07:57.576Z","creation":"2026-05-20T03:14:53.365Z"},"accession":"S-EPMC12644464","cross_references":{"pubmed":["41285716"],"doi":["10.1038/s41419-025-08144-4"]}}