{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Aimaganova A"],"funding":["National Institute for Health Research, UK"],"pagination":["41542"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12644497"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["Altered thyroid function (TF), especially non-thyroidal illness syndrome (NTIS), is common in hospitalised COVID-19 patients, but adaptive responses to disease as captured by blood biomarkers in the context of thyroid signal integration require further elucidation. This retrospective study analysed 29 routine biomarkers, including immune, inflammatory, haematological, organ damage, and TF markers, from patients admitted to the University Hospital Coventry and Warwickshire, decoding associations of the biomarkers with TF key determinants and identifying patterns of severity-specific thyroid dysfunction. Patients were categorised by disease severity based on admission to either critical care units (CCU) or general wards. Among 237 records, 140 were CCU admissions (mean age 57, 69% male) and "],"journal":["Scientific reports"],"pubmed_title":["Dissecting biomarker networks linking COVID-19 inflammatory drivers, disease severity and thyroid adaptive responses."],"pmcid":["PMC12644497"],"funding_grant_id":["03122020"],"pubmed_authors":["Anderson NR","Vryonis E","Khovanova N","Grammatopoulos DK","Aimaganova A","Braybrook E","Young L"],"additional_accession":[]},"is_claimable":false,"name":"Dissecting biomarker networks linking COVID-19 inflammatory drivers, disease severity and thyroid adaptive responses.","description":"Altered thyroid function (TF), especially non-thyroidal illness syndrome (NTIS), is common in hospitalised COVID-19 patients, but adaptive responses to disease as captured by blood biomarkers in the context of thyroid signal integration require further elucidation. This retrospective study analysed 29 routine biomarkers, including immune, inflammatory, haematological, organ damage, and TF markers, from patients admitted to the University Hospital Coventry and Warwickshire, decoding associations of the biomarkers with TF key determinants and identifying patterns of severity-specific thyroid dysfunction. Patients were categorised by disease severity based on admission to either critical care units (CCU) or general wards. Among 237 records, 140 were CCU admissions (mean age 57, 69% male) and ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-05T18:54:32.069Z","creation":"2026-05-20T03:14:39.784Z"},"accession":"S-EPMC12644497","cross_references":{"pubmed":["41286140"],"doi":["10.1038/s41598-025-25434-1"]}}