{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["133(11)"],"submitter":["Lee HJ"],"pubmed_abstract":["<h4>Background</h4>Cancer metastasis, primarily driven by epithelial-to-mesenchymal transition (EMT), is responsible for most cancer-related mortalities. Traditional pre-clinical models fail to fully capture mesenchymal characteristics due to the loss of human stroma. The extracellular matrix (ECM) plays a crucial role in EMT, yet conventional in vitro models often rely on defined ECM components, which may not adequately replicate the human physiological ECM niche.<h4>Methods</h4>To mimic the in situ dissemination of cancer cells, we employed a patient-derived extracellular matrix (pdECM). We transitioned the culture matrix for patient-derived colorectal cancer organoids from a basement membrane extract (BME) to a patient-derived ECM (pdECM). We performed single-cell multiomic analyses, in"],"journal":["British journal of cancer"],"pagination":["1708-1719"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12644670"],"repository":["biostudies-literature"],"pubmed_title":["Single-cell multiomic modelling of early metastatic events promoted by the extracellular matrix."],"pmcid":["PMC12644670"],"pubmed_authors":["Park JE","Cho Y","Kim TY","Park J","Choi JK","Kim K","Park WY","Kwon J","Song SH","Kim P","Kim YJ","Lee HJ","Kang J","Lee JH"],"additional_accession":[]},"is_claimable":false,"name":"Single-cell multiomic modelling of early metastatic events promoted by the extracellular matrix.","description":"<h4>Background</h4>Cancer metastasis, primarily driven by epithelial-to-mesenchymal transition (EMT), is responsible for most cancer-related mortalities. Traditional pre-clinical models fail to fully capture mesenchymal characteristics due to the loss of human stroma. The extracellular matrix (ECM) plays a crucial role in EMT, yet conventional in vitro models often rely on defined ECM components, which may not adequately replicate the human physiological ECM niche.<h4>Methods</h4>To mimic the in situ dissemination of cancer cells, we employed a patient-derived extracellular matrix (pdECM). We transitioned the culture matrix for patient-derived colorectal cancer organoids from a basement membrane extract (BME) to a patient-derived ECM (pdECM). We performed single-cell multiomic analyses, in","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-06T15:46:38.247Z","creation":"2026-06-02T03:09:33.37Z"},"accession":"S-EPMC12644670","cross_references":{"pubmed":["40954257"],"doi":["10.1038/s41416-025-03181-4"]}}