{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Elsharkawy A"],"pubmed_abstract":["The design focus of the first-generation COVID-19 vaccines was on the use of the SARS-CoV-2 spike (S) protein as the primary vaccine immunogen to induce high levels of neutralizing antibodies. Efficacy was repeatedly disrupted due to the diminished neutralizing capacity of vaccine-induced antibodies against emerging variants. Vaccine candidate GEO-CM04S1 is based on the use of a modified vaccinia Ankara vector (MVA) that co-expresses S and nucleocapsid (N) antigens of the Wuhan-Hu-1 reference strain. It is designed to induce both antibody and T-cell responses to both S and N, with the goal of broadening immune response specificity and function. Herein, we characterized GEO-CM04S1 vaccine induced immune responses and efficacy against the ancestral Wuhan strain B.1 and the Omicron subvariant"],"journal":["Frontiers in immunology"],"pagination":["1694699"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12645453"],"repository":["biostudies-literature"],"pubmed_title":["Multi-antigen MVA-vectored SARS-CoV-2 vaccine, GEO-CM04S1, induces cross-protective immune responses to ancestral and Omicron variants."],"pmcid":["PMC12645453"],"pubmed_authors":["Burleson JD","Albrecht TR","Diamond DJ","Elsharkawy A","Oruganti SR","Dim C","Newman M","Wussow F","Kumar M","Hauser M","Domi A","Guglani A","Kumari P","Stone S"],"additional_accession":[]},"is_claimable":false,"name":"Multi-antigen MVA-vectored SARS-CoV-2 vaccine, GEO-CM04S1, induces cross-protective immune responses to ancestral and Omicron variants.","description":"The design focus of the first-generation COVID-19 vaccines was on the use of the SARS-CoV-2 spike (S) protein as the primary vaccine immunogen to induce high levels of neutralizing antibodies. Efficacy was repeatedly disrupted due to the diminished neutralizing capacity of vaccine-induced antibodies against emerging variants. Vaccine candidate GEO-CM04S1 is based on the use of a modified vaccinia Ankara vector (MVA) that co-expresses S and nucleocapsid (N) antigens of the Wuhan-Hu-1 reference strain. It is designed to induce both antibody and T-cell responses to both S and N, with the goal of broadening immune response specificity and function. Herein, we characterized GEO-CM04S1 vaccine induced immune responses and efficacy against the ancestral Wuhan strain B.1 and the Omicron subvariant","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-05-20T03:22:31.766Z","creation":"2026-05-20T03:14:42.132Z"},"accession":"S-EPMC12645453","cross_references":{"pubmed":["41306976"],"doi":["10.3389/fimmu.2025.1694699"]}}