{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Langa S"],"funding":["Ministerio de Ciencia, Innovaci??n y Universidades"],"pagination":["4520-4532"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12645574"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(11)"],"pubmed_abstract":["Equol (EQ) and its analogous derivatives 5-hydroxy-equol (5-OH-EQ) and 5-hydroxy-dehydroequol (5-OH-D-EQ) are isoflavones which benefit human health. They are produced from daidzein and genistein, respectively, in the gut by microorganisms harboring the genes daidzein reductase (<i>dzr</i>), dihydrodaidzein racemase (<i>ifc</i>A), dihydrodaidzein reductase (<i>ddr</i>) and tetrahydrodaidzein reductase (<i>tdr</i>). Since the production of these isoflavones is of interest due to their great-health benefits for humans, the heterologous expression of <i>dzr</i>, <i>ddr</i>, <i>tdr</i> and <i>ifc</i>A from <i>Slackia isoflavoniconvertenes</i> DSM 22006T in lactic acid bacteria (LAB) was used as a strategy to produce EQ, 5-OH-EQ and 5-OH-D-EQ in soy beverages. However, efficient production of t"],"journal":["ACS synthetic biology"],"pubmed_title":["The Translational Coupling of Daidzein Reductase and Dihydrodaidzein Racemase Genes Improves the Production of Equol and Its Analogous Derivatives in Engineered Lactic Acid Bacteria."],"pmcid":["PMC12645574"],"funding_grant_id":["PID2020-119630RB-I00"],"pubmed_authors":["Curiel JA","Langa S","Peiroten A","Landete JM"],"additional_accession":[]},"is_claimable":false,"name":"The Translational Coupling of Daidzein Reductase and Dihydrodaidzein Racemase Genes Improves the Production of Equol and Its Analogous Derivatives in Engineered Lactic Acid Bacteria.","description":"Equol (EQ) and its analogous derivatives 5-hydroxy-equol (5-OH-EQ) and 5-hydroxy-dehydroequol (5-OH-D-EQ) are isoflavones which benefit human health. They are produced from daidzein and genistein, respectively, in the gut by microorganisms harboring the genes daidzein reductase (<i>dzr</i>), dihydrodaidzein racemase (<i>ifc</i>A), dihydrodaidzein reductase (<i>ddr</i>) and tetrahydrodaidzein reductase (<i>tdr</i>). Since the production of these isoflavones is of interest due to their great-health benefits for humans, the heterologous expression of <i>dzr</i>, <i>ddr</i>, <i>tdr</i> and <i>ifc</i>A from <i>Slackia isoflavoniconvertenes</i> DSM 22006T in lactic acid bacteria (LAB) was used as a strategy to produce EQ, 5-OH-EQ and 5-OH-D-EQ in soy beverages. However, efficient production of t","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-05T18:52:15.942Z","creation":"2026-05-20T03:14:13.643Z"},"accession":"S-EPMC12645574","cross_references":{"pubmed":["41133761"],"doi":["10.1021/acssynbio.5c00532"]}}