biostudies-literatureUnknown15(11)Lowrie R<h4>Introduction</h4>People experiencing severe and multiple disadvantage (SMD: homelessness, substance use and criminal offending) have multiple intersecting unmet health and social care needs and high mortality rates, often due to street-drug overdose. Pilot randomised controlled trials (RCTs) suggest an integrated, holistic, collaborative outreach intervention (Pharmacy Homeless Outreach Engagement Non-medical Independent Prescribing Rx (PHOENIx)) involving generalist-trained pharmacists, nurses or General Practitioners accompanied by staff from third sector homeless organisations may improve outcomes, including reducing overdose.<h4>Methods</h4>Multicentre, parallel group, prospective RCT with parallel economic and process evaluation. Set in six areas of Scotland, UK, 378 adults with SBMJ opene106640https://www.ebi.ac.uk/biostudies/studies/S-EPMC12645644biostudies-literatureProtocol for a multicentre randomised controlled trial of the Pharmacy Homeless Outreach Engagement Non-medical and Independent Prescriber (PHOENIx) intervention for people facing severe and multiple disadvantages.PMC12645644Vickery KMacLean GKelly SWilliamson AEMcGilvery EAdam ASutherland ARushworth GGarstka ZMelville LRowe AOrr TThomson EMaclean ABreingan ZLilley JMacaulay MPaudyal VMurphy JCortez MAMarshall TDos Santos CRaeburn FBudd JStoddart ADuncan GMoir JMcKinney ELewis SMcPherson AKennedy HAli Akbar HNelson KJohnsen SRobertson COrr MCarnegie JO'Loan JRosinska MLowrie REsson KfalseProtocol for a multicentre randomised controlled trial of the Pharmacy Homeless Outreach Engagement Non-medical and Independent Prescriber (PHOENIx) intervention for people facing severe and multiple disadvantages.<h4>Introduction</h4>People experiencing severe and multiple disadvantage (SMD: homelessness, substance use and criminal offending) have multiple intersecting unmet health and social care needs and high mortality rates, often due to street-drug overdose. Pilot randomised controlled trials (RCTs) suggest an integrated, holistic, collaborative outreach intervention (Pharmacy Homeless Outreach Engagement Non-medical Independent Prescribing Rx (PHOENIx)) involving generalist-trained pharmacists, nurses or General Practitioners accompanied by staff from third sector homeless organisations may improve outcomes, including reducing overdose.<h4>Methods</h4>Multicentre, parallel group, prospective RCT with parallel economic and process evaluation. Set in six areas of Scotland, UK, 378 adults with S2025-01-01T00:00:00Z2025 Nov2026-06-05T19:01:23.321Z2026-05-20T03:14:27.936ZS-EPMC126456444128550010.1136/bmjopen-2025-106640