biostudies-literatureSreedevi KNHLBI NIH HHS1-12https://www.ebi.ac.uk/biostudies/studies/S-EPMC12646366biostudies-literatureUnknown198PERM1 was initially identified as a new downstream target of PGC-1α and ERRs that regulates mitochondrial bioenergetics in skeletal muscle. Subsequently, we and other groups demonstrated that PERM1 is also a positive regulator of mitochondrial bioenergetics in the heart. However, the exact mechanisms of regulatory functions of PERM1 remain poorly understood. O-GlcNAcylation is a post-translational modification of proteins that are regulated by two enzymes: O-GlcNAc transferase (OGT) that adds O-GlcNAc to proteins; O-GlcNAcase (OGA) that removes O-GlcNAc from proteins. O-GlcNAcylation is a powerful signaling mechanism mediating cellular responses to stressors and nutrient availability, which, among other targets, may influence cardiac metabolism. We hypothesized that PERM1 regulates mitochoJournal of molecular and cellular cardiologyPERM1 regulates mitochondrial energetics through O-GlcNAcylation in the heart.PMC12646366R01 HL156667Wende ARWarren JSZaitsev AVJames AYedla SArowa SSreedevi KDo SOka SIfalsePERM1 regulates mitochondrial energetics through O-GlcNAcylation in the heart.PERM1 was initially identified as a new downstream target of PGC-1α and ERRs that regulates mitochondrial bioenergetics in skeletal muscle. Subsequently, we and other groups demonstrated that PERM1 is also a positive regulator of mitochondrial bioenergetics in the heart. However, the exact mechanisms of regulatory functions of PERM1 remain poorly understood. O-GlcNAcylation is a post-translational modification of proteins that are regulated by two enzymes: O-GlcNAc transferase (OGT) that adds O-GlcNAc to proteins; O-GlcNAcase (OGA) that removes O-GlcNAc from proteins. O-GlcNAcylation is a powerful signaling mechanism mediating cellular responses to stressors and nutrient availability, which, among other targets, may influence cardiac metabolism. We hypothesized that PERM1 regulates mitocho2025-01-01T00:00:00Z2025 Jan2026-06-06T08:57:12.519Z2026-05-28T03:11:32.092ZS-EPMC126463663958116110.1016/j.yjmcc.2024.11.002