biostudies-literatureJohnson SRNHLBI NIH HHS1182-1200https://www.ebi.ac.uk/biostudies/studies/S-EPMC12646471biostudies-literatureUnknown76(8)<h4>Objective</h4>We provide evidence-based recommendations regarding the treatment of interstitial lung disease (ILD) in adults with systemic autoimmune rheumatic diseases (SARDs).<h4>Methods</h4>We developed clinically relevant population, intervention, comparator, and outcomes questions. A systematic literature review was then performed, and the available evidence was rated using the Grading of Recommendations, Assessment, Development, and Evaluation methodology. A panel of clinicians and patients reached consensus on the direction and strength of the recommendations.<h4>Results</h4>Thirty-five recommendations were generated (including two strong recommendations) for first-line SARD-ILD treatment, treatment of SARD-ILD progression despite first-line ILD therapy, and treatment of rapidlyArthritis & rheumatology (Hoboken, N.J.)2023 American College of Rheumatology (ACR)/American College of Chest Physicians (CHEST) Guideline for the Treatment of Interstitial Lung Disease in People with Systemic Autoimmune Rheumatic Diseases.PMC12646471R01 HL169166R01 HL166290McMahan ZHNatalini JGGuyatt GSolomon JJMcDermott GCLee JSSaygin DAgarwal SKBolster MBWarrier ASingh NOldham JMHallowell RDomsic RTVaseer SBemiss BCorwin DSDematte D'Amico JEMakol AMerck SJHinze AMSummer RJiwrajka NLakin KSChami HAShapiro LAntin-Ozerkis DChung JHDellaripa PFFrech TMKim JSDoyle TJKanne JPChowdhary VHinchcliff MNesbitt KLim SYMirza RDGibbons FKJohnson SRAggarwal RJoerns EKKhanna DTurner ABernstein EJScholand MBSparks JAUhl SAssassi SJohnson CBuckley LGeorge MDVarga JTurgunbaev MAllen AFalardeau CMMatson SInjean PADanoff SKSharkey CDIvlev Ifalse2023 American College of Rheumatology (ACR)/American College of Chest Physicians (CHEST) Guideline for the Treatment of Interstitial Lung Disease in People with Systemic Autoimmune Rheumatic Diseases.<h4>Objective</h4>We provide evidence-based recommendations regarding the treatment of interstitial lung disease (ILD) in adults with systemic autoimmune rheumatic diseases (SARDs).<h4>Methods</h4>We developed clinically relevant population, intervention, comparator, and outcomes questions. A systematic literature review was then performed, and the available evidence was rated using the Grading of Recommendations, Assessment, Development, and Evaluation methodology. A panel of clinicians and patients reached consensus on the direction and strength of the recommendations.<h4>Results</h4>Thirty-five recommendations were generated (including two strong recommendations) for first-line SARD-ILD treatment, treatment of SARD-ILD progression despite first-line ILD therapy, and treatment of rapidly2024-01-01T00:00:00Z2024 Aug2026-06-05T19:03:55.825Z2026-05-20T03:14:52.605ZS-EPMC126464713897831010.1002/art.42861