{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["77(6)"],"submitter":["Luszczki JJ"],"pubmed_abstract":["<h4>Background</h4>The isobolographic analysis is a gold standard in the assessment of interactions between drugs in experimental studies. Although some isobolographic approaches are available, the most popular methods to characterize drug-drug interactions are the log-probit method accompanied with statistical analysis of interactions (by Tallarida) and the method based on mass-action law using CompuSyn software (elaborated by Chou-Talalay-Martin). The aim of this study was to compare the results from these two isobolographic approaches.<h4>Methods</h4>Two isobolographic methods (log-probit associated with Tallarida statistics and Chou-Talalay-Martin) were applied to analyze the interaction between two antiseizure medications - clonazepam and lamotrigine in the mouse maximal electroshock-"],"journal":["Pharmacological reports : PR"],"pagination":["1760-1767"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12647196"],"repository":["biostudies-literature"],"pubmed_title":["Log-probit accompanied with Tallarida and Chou-Talalay-Martin methods in an isobolographic analysis of interactions between two antiseizure medications - a comparative study."],"pmcid":["PMC12647196"],"pubmed_authors":["Luszczki JJ","Gustaw-Rothenberg K","Florek-Luszczki M"],"additional_accession":[]},"is_claimable":false,"name":"Log-probit accompanied with Tallarida and Chou-Talalay-Martin methods in an isobolographic analysis of interactions between two antiseizure medications - a comparative study.","description":"<h4>Background</h4>The isobolographic analysis is a gold standard in the assessment of interactions between drugs in experimental studies. Although some isobolographic approaches are available, the most popular methods to characterize drug-drug interactions are the log-probit method accompanied with statistical analysis of interactions (by Tallarida) and the method based on mass-action law using CompuSyn software (elaborated by Chou-Talalay-Martin). The aim of this study was to compare the results from these two isobolographic approaches.<h4>Methods</h4>Two isobolographic methods (log-probit associated with Tallarida statistics and Chou-Talalay-Martin) were applied to analyze the interaction between two antiseizure medications - clonazepam and lamotrigine in the mouse maximal electroshock-","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-05-18T03:20:38.251Z","creation":"2026-05-18T03:13:18.84Z"},"accession":"S-EPMC12647196","cross_references":{"pubmed":["40911251"],"doi":["10.1007/s43440-025-00784-9"]}}