{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Guo Z"],"funding":["The Key projects of Qilu Hospital (Qingdao) Foundation"],"pagination":["41774"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12647232"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["Intracranial aneurysm (IA) is a type of cerebrovascular complication that can result in subarachnoid hemorrhage. Published research have evidenced the involvement of METTL3, a critical mRNA m<sup>6</sup>A methyltransferase, in the generation of various cardiovascular diseases. However, its specific role in regulating IAs remains unclear. Our research demonstrated downregulation of METTL3 in IA patients and a significant positive correlation with AMPK expression. In vascular smooth muscle cells (VSMCs), overexpressing METTL3 led to an upregulation of contractile marker genes (SM-22α & α-SMA), while the expressions of TNF-α, IL-1β, iNOS, IL-6, MMP-9, and MMP-3 were significantly downregulated. This effect was reversed by the use of the AMPK inhibitor Compound C. Therefore, it can be postulat"],"journal":["Scientific reports"],"pubmed_title":["METTL3 promotes vascular stability in intracranial aneurysm via m6A-AMPK axis."],"pmcid":["PMC12647232"],"funding_grant_id":["QDKY2020ZD01"],"pubmed_authors":["Guo Z","Zhong Y","Wang Y","Ming Z"],"additional_accession":[]},"is_claimable":false,"name":"METTL3 promotes vascular stability in intracranial aneurysm via m6A-AMPK axis.","description":"Intracranial aneurysm (IA) is a type of cerebrovascular complication that can result in subarachnoid hemorrhage. Published research have evidenced the involvement of METTL3, a critical mRNA m<sup>6</sup>A methyltransferase, in the generation of various cardiovascular diseases. However, its specific role in regulating IAs remains unclear. Our research demonstrated downregulation of METTL3 in IA patients and a significant positive correlation with AMPK expression. In vascular smooth muscle cells (VSMCs), overexpressing METTL3 led to an upregulation of contractile marker genes (SM-22α & α-SMA), while the expressions of TNF-α, IL-1β, iNOS, IL-6, MMP-9, and MMP-3 were significantly downregulated. This effect was reversed by the use of the AMPK inhibitor Compound C. Therefore, it can be postulat","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-05T16:41:24.066Z","creation":"2026-05-18T03:12:56.734Z"},"accession":"S-EPMC12647232","cross_references":{"pubmed":["41290742"],"doi":["10.1038/s41598-025-25685-y"]}}