{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lee G"],"funding":["National Research Foundation of Korea (NRF)","Ministry of Health and Welfare (Ministry of Health, Welfare and Family Affairs)"],"pagination":["10439"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12647634"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["Endometrial receptivity is a critical determinant of embryo implantation and early pregnancy success; however, current methods for assessing endometrial receptivity remain poorly validated and insufficiently reliable for clinical application. Here, we establish a patient-derived vascularised endometrium-on-a-chip (EoC), successfully replicating the dynamic microenvironment and both temporal and spatial architecture of native endometrial tissue. Using our EoC, we develop a clinically relevant endometrial receptivity scoring system, ERS<sup>2</sup>, which integrates molecular profiling of established receptivity markers with quantitative analyses of angiogenesis. The ERS<sup>2</sup> enables personalised assessment of endometrial health and implantation potential, addressing inter-patient var"],"journal":["Nature communications"],"pubmed_title":["Microengineered patient-derived endometrium-on-a-chip for the evaluation of endometrial receptivity and personalised translational medicine."],"pmcid":["PMC12647634"],"funding_grant_id":["RS-2025-02214614","RS-2023-00240820","RS-2024-00338274","RS-2024-00406054"],"pubmed_authors":["Kim YY","Kang YJ","Ahn J","Hwang SY","Lee J","Koo HS","Ku SY","Lee YG","Yu WJ","Lee G","Lee D","Park JC"],"additional_accession":[]},"is_claimable":false,"name":"Microengineered patient-derived endometrium-on-a-chip for the evaluation of endometrial receptivity and personalised translational medicine.","description":"Endometrial receptivity is a critical determinant of embryo implantation and early pregnancy success; however, current methods for assessing endometrial receptivity remain poorly validated and insufficiently reliable for clinical application. Here, we establish a patient-derived vascularised endometrium-on-a-chip (EoC), successfully replicating the dynamic microenvironment and both temporal and spatial architecture of native endometrial tissue. Using our EoC, we develop a clinically relevant endometrial receptivity scoring system, ERS<sup>2</sup>, which integrates molecular profiling of established receptivity markers with quantitative analyses of angiogenesis. The ERS<sup>2</sup> enables personalised assessment of endometrial health and implantation potential, addressing inter-patient var","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-05T16:41:25.065Z","creation":"2026-05-18T03:12:56.864Z"},"accession":"S-EPMC12647634","cross_references":{"pubmed":["41290570"],"doi":["10.1038/s41467-025-65406-7"]}}