biostudies-literatureTirado MPAgencia Estatal de Investigación41788https://www.ebi.ac.uk/biostudies/studies/S-EPMC12647829biostudies-literatureUnknown15(1)The cerebellar granular layer plays a central role in sensory processing and pattern separation through its distinctive feedforward architecture. Here, we present a biologically realistic computational model of the granular layer designed to explore the functional impact of synaptic inhibition mediated by Golgi cells. The model integrates anatomical and physiological constraints to simulate realistic mossy fiber activity patterns, including spatial correlations and varying activation levels. We validate the model by replicating key findings from recent in vivo experiments, such as the role of inhibition in shaping granule cell responsiveness and the emergence of nonlinear suppression during multisensory integration. Beyond validation, the model provides a robust computational tool for studScientific reportsA computational model of the cerebellar granular layer calibrated to experimental data for studying inhibition and sensory encoding.PMC12647829PID2020-113422GA-I00 (2020)Tirado MPGarrido JAOrtigosa EMRos EfalseA computational model of the cerebellar granular layer calibrated to experimental data for studying inhibition and sensory encoding.The cerebellar granular layer plays a central role in sensory processing and pattern separation through its distinctive feedforward architecture. Here, we present a biologically realistic computational model of the granular layer designed to explore the functional impact of synaptic inhibition mediated by Golgi cells. The model integrates anatomical and physiological constraints to simulate realistic mossy fiber activity patterns, including spatial correlations and varying activation levels. We validate the model by replicating key findings from recent in vivo experiments, such as the role of inhibition in shaping granule cell responsiveness and the emergence of nonlinear suppression during multisensory integration. Beyond validation, the model provides a robust computational tool for stud2025-01-01T00:00:00Z2025 Nov2026-06-05T16:41:36.248Z2026-05-18T03:13:01.02ZS-EPMC126478294129076310.1038/s41598-025-25727-5