biostudies-literatureUnknown15(11)Chen WAcute respiratory distress syndrome (ARDS) is the leading cause of respiratory failure with high morbidity and mortality. Pulmonary surfactant (PS)-based complementary therapies have exhibited potential for ARDS healing and applied as an adjunctive therapy strategy. Coacervate (Coac) has the characteristics of softness, deformability and excellent molecular enrichment properties, and has attracted extensive attention in the biomedical field. Here PS and coacervate were combined for the potential ARDS treatment. The Coac, fabricated from polyallylamine hydrochloride (PAH) and adenosine triphosphate (ATP) by simple mixing, exhibited soft droplet property and high enrichment for dexamethasone sodium phosphate (DSP). To avoid the fusion effect of membraneless coacervate and endow it with bioloActa pharmaceutica Sinica. B5945-5965https://www.ebi.ac.uk/biostudies/studies/S-EPMC12648001biostudies-literaturePulmonary surfactant-biomimetic membranized coacervate injection for acute respiratory distress syndrome therapy.PMC12648001Li YKong LFu CZhang ZZhang HChen WGao YXie QKang JYang CZhou ZBatur SfalsePulmonary surfactant-biomimetic membranized coacervate injection for acute respiratory distress syndrome therapy.Acute respiratory distress syndrome (ARDS) is the leading cause of respiratory failure with high morbidity and mortality. Pulmonary surfactant (PS)-based complementary therapies have exhibited potential for ARDS healing and applied as an adjunctive therapy strategy. Coacervate (Coac) has the characteristics of softness, deformability and excellent molecular enrichment properties, and has attracted extensive attention in the biomedical field. Here PS and coacervate were combined for the potential ARDS treatment. The Coac, fabricated from polyallylamine hydrochloride (PAH) and adenosine triphosphate (ATP) by simple mixing, exhibited soft droplet property and high enrichment for dexamethasone sodium phosphate (DSP). To avoid the fusion effect of membraneless coacervate and endow it with biolo2025-01-01T00:00:00Z2025 Nov2026-06-05T17:56:37.214Z2026-05-19T03:12:08.74ZS-EPMC126480014131138410.1016/j.apsb.2025.08.025