{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["5(11)"],"submitter":["Zhu W"],"pubmed_abstract":["Targeted protein degradation (TPD) has emerged as a promising therapeutic strategy, with advantages over traditional protein inhibition. Despite significant advancements in novel degraders such as bivalents and multitargeting proteolysis-targeting chimeras (PROTACs), key challenges persist in the development pipeline, particularly regarding the identification of highly potent degraders and the optimization of their drug-like properties. Here, we reported a multimodal modular assembled targeting chimera (multi-MOATAC) strategy that enabled intracellular click chemistry-mediated <i>in situ</i> assembly of ligand modules with targets, integrating multiple functional units into binary/ternary complexes. This strategy validated significantly enhanced degradation efficiency via trivalent self-as"],"journal":["JACS Au"],"pagination":["5635-5647"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12648310"],"repository":["biostudies-literature"],"pubmed_title":["Modular Assembled Targeting Chimera Enables Multimodal Targeted Protein Degradation."],"pmcid":["PMC12648310"],"pubmed_authors":["Zhang W","Chen J","Xu F","Pang J","Zhu W","Wang Y"],"additional_accession":[]},"is_claimable":false,"name":"Modular Assembled Targeting Chimera Enables Multimodal Targeted Protein Degradation.","description":"Targeted protein degradation (TPD) has emerged as a promising therapeutic strategy, with advantages over traditional protein inhibition. Despite significant advancements in novel degraders such as bivalents and multitargeting proteolysis-targeting chimeras (PROTACs), key challenges persist in the development pipeline, particularly regarding the identification of highly potent degraders and the optimization of their drug-like properties. Here, we reported a multimodal modular assembled targeting chimera (multi-MOATAC) strategy that enabled intracellular click chemistry-mediated <i>in situ</i> assembly of ligand modules with targets, integrating multiple functional units into binary/ternary complexes. This strategy validated significantly enhanced degradation efficiency via trivalent self-as","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-05T17:59:33.094Z","creation":"2026-05-19T03:12:16.596Z"},"accession":"S-EPMC12648310","cross_references":{"pubmed":["41311923"],"doi":["10.1021/jacsau.5c01131"]}}