biostudies-literatureUnknown8(11)Le Rhun E<h4>Importance</h4>Proton pump inhibitors (PPI) are often prescribed to prevent steroid-induced gastritis and peptic ulcer disease in patients with glioblastoma. Yet, these drugs may enhance the activity of aldehyde dehydrogenase 1 A1 (ALDH1A1), which has been linked to protection from oxidative stress, radiotherapy, and chemotherapy.<h4>Objective</h4>To explore the associations of the use of potent ALDH1A1-activating PPIs (PA-PPIs) and other antacid drugs with outcomes in patients with newly diagnosed glioblastoma.<h4>Design, setting, and participants</h4>This meta-analysis was a secondary analysis of individual prospectively captured patient data using a dataset of 5 randomized clinical trials conducted between 2008 and 2020. Participants included patients with a new diagnosis of glioblaJAMA network opene2545578https://www.ebi.ac.uk/biostudies/studies/S-EPMC12648345biostudies-literatureProton Pump Inhibitor Use and Survival in Patients With Newly Diagnosed Glioblastoma.PMC12648345Weller MCloughesy TErridge SCNabors BReardon DAPreusser MLe Rhun EMinniti GWick WStupp RSampson JMason WReijneveld JCGorlia TSain DRoth PfalseProton Pump Inhibitor Use and Survival in Patients With Newly Diagnosed Glioblastoma.<h4>Importance</h4>Proton pump inhibitors (PPI) are often prescribed to prevent steroid-induced gastritis and peptic ulcer disease in patients with glioblastoma. Yet, these drugs may enhance the activity of aldehyde dehydrogenase 1 A1 (ALDH1A1), which has been linked to protection from oxidative stress, radiotherapy, and chemotherapy.<h4>Objective</h4>To explore the associations of the use of potent ALDH1A1-activating PPIs (PA-PPIs) and other antacid drugs with outcomes in patients with newly diagnosed glioblastoma.<h4>Design, setting, and participants</h4>This meta-analysis was a secondary analysis of individual prospectively captured patient data using a dataset of 5 randomized clinical trials conducted between 2008 and 2020. Participants included patients with a new diagnosis of gliobla2025-01-01T00:00:00Z2025 Nov2026-06-05T19:55:47.653Z2026-05-21T03:09:22.198ZS-EPMC126483454128897210.1001/jamanetworkopen.2025.45578