{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Zhen W"],"pubmed_abstract":["<h4>Background</h4>Although low tidal volume ventilation has been shown to reduce mortality in patients with acute respiratory distress syndrome (ARDS), overall mortality remains high (30%-40%). Ultra-protective ventilation (≤4 mL/kg predicted body weight) has the potential to further decrease ventilator-induced lung injury but may result in severe hypercapnia. Extracorporeal carbon dioxide removal (ECCO<sub>2</sub>R) could facilitate ultra-protective ventilation by alleviating carbon dioxide retention; however, supporting evidence remains limited.<h4>Objective</h4>To evaluate the efficacy of ECCO<sub>2</sub>R in enabling ultra-protective ventilation strategies in patients with ARDS.<h4>Methods</h4>A systematic search was conducted in PubMed, Embase, Web of Science, and the Cochrane Librar"],"journal":["Frontiers in medicine"],"pagination":["1707596"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12648385"],"repository":["biostudies-literature"],"pubmed_title":["Effects of extracorporeal carbon dioxide removal in facilitating ultra-protective ventilation strategies for patients with acute respiratory distress syndrome: a systematic review and meta-analysis."],"pmcid":["PMC12648385"],"pubmed_authors":["Zhen W","Zhu Y","Zhang X","Shi Z"],"additional_accession":[]},"is_claimable":false,"name":"Effects of extracorporeal carbon dioxide removal in facilitating ultra-protective ventilation strategies for patients with acute respiratory distress syndrome: a systematic review and meta-analysis.","description":"<h4>Background</h4>Although low tidal volume ventilation has been shown to reduce mortality in patients with acute respiratory distress syndrome (ARDS), overall mortality remains high (30%-40%). Ultra-protective ventilation (≤4 mL/kg predicted body weight) has the potential to further decrease ventilator-induced lung injury but may result in severe hypercapnia. Extracorporeal carbon dioxide removal (ECCO<sub>2</sub>R) could facilitate ultra-protective ventilation by alleviating carbon dioxide retention; however, supporting evidence remains limited.<h4>Objective</h4>To evaluate the efficacy of ECCO<sub>2</sub>R in enabling ultra-protective ventilation strategies in patients with ARDS.<h4>Methods</h4>A systematic search was conducted in PubMed, Embase, Web of Science, and the Cochrane Librar","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-05T16:40:29.31Z","creation":"2026-06-05T03:06:52.821Z"},"accession":"S-EPMC12648385","cross_references":{"pubmed":["41312468"],"doi":["10.3389/fmed.2025.1707596"]}}