biostudies-literatureUnknown82Zamora V<h4>Background and objective</h4>Our objective was to compare the impact of open radical prostatectomy (RP), external beam radiotherapy (EBRT), and brachytherapy in patients with localized prostate cancer via patient-reported outcome measures up to 20 yr after treatment.<h4>Methods</h4>This was a prospective observational study (ClinicalTrials.gov NCT01492751) of men with localized prostate cancer (clinical stage T1-T2, low or intermediate risk). The Expanded Prostate Cancer Index Composite (EPIC-26) and Short Form-36 (SF-36) questionnaires were centrally administered via telephone interviews before treatment and then annually after treatment. Generalized estimating equation models were constructed with propensity score-based weights.<h4>Key findings and limitations</h4>The RP group reportEuropean urology open science160-167https://www.ebi.ac.uk/biostudies/studies/S-EPMC12648591biostudies-literatureTwenty-year Patient-reported Outcomes After Surgery, Radiotherapy, or Brachytherapy for Localized Prostate Cancer.PMC12648591Ventura MSancho GBonet XAlonso Jde Paula BOrtiz MJSuarez JFGoni AGarin OFerrer FPont APalou JHerruzo Ide Leon JPGuedea FCabrera PAvila MMacias VFernandez PFerrer MPonce de Leon JCastells MPastor SGutierrez CPardo YHervas AMulticenter Spanish Group for Clinically Localized Prostate CancerSole JBonet CMarino AZamora VBoladeras ARamos ABonet MfalseTwenty-year Patient-reported Outcomes After Surgery, Radiotherapy, or Brachytherapy for Localized Prostate Cancer.<h4>Background and objective</h4>Our objective was to compare the impact of open radical prostatectomy (RP), external beam radiotherapy (EBRT), and brachytherapy in patients with localized prostate cancer via patient-reported outcome measures up to 20 yr after treatment.<h4>Methods</h4>This was a prospective observational study (ClinicalTrials.gov NCT01492751) of men with localized prostate cancer (clinical stage T1-T2, low or intermediate risk). The Expanded Prostate Cancer Index Composite (EPIC-26) and Short Form-36 (SF-36) questionnaires were centrally administered via telephone interviews before treatment and then annually after treatment. Generalized estimating equation models were constructed with propensity score-based weights.<h4>Key findings and limitations</h4>The RP group report2025-01-01T00:00:00Z2025 Dec2026-06-05T18:46:38.891Z2026-05-20T03:13:22.796ZS-EPMC126485914131164010.1016/j.euros.2025.10.007