{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Llaurador-Coll M"],"funding":["Generalitat de Catalunya","Carlos III Health Institute","European Innovation Council","Stiftelsen för Gamla Tjänarinnor","Rovira i Virgili University","Ministerio de Ciencia e Innovación","Swedish Research Council","Alzheimer&apos;s Association","Alzheimer Fund","Gobierno de Espana Ministerio de Ciencia e Innovacion","European Regional Development Fund","Government of Catalonia Agency for Administration of University and Research Grants"],"pagination":["101134"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12648619"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["50"],"pubmed_abstract":["<h4>Background</h4>Early diagnosis of psychosis is crucial, and biomarker detection may provide insights into the pathophysiology of psychosis and the potential for the development of early diagnostic tools. In particular, blood-based proteomic profiling has yielded promising results for psychiatric disorders because of the use of novel high-throughput techniques and the feasibility of performing blood extractions in routine clinical practice.<h4>Study design and methodology</h4>Here, we studied 182 participants (33.3 % females, X‾ <sub>age</sub> = 24.66 ± 5.05), comprising 50 healthy controls (HCs), 37 patients with an at-risk mental state (ARMS) and 95 patients with a first episode of psychosis (FEP). We used a panel of 92 neurology-related proteins in a multiplex immunoassay to identify"],"journal":["Brain, behavior, & immunity - health"],"pubmed_title":["Plasma profiles of neurology-related proteins in at-risk mental state and first-episode psychosis: Associations with psychotic symptoms and cognitive performance."],"pmcid":["PMC12648619"],"funding_grant_id":["-22-974564","2022-01018","AF-940262","ALFGBG-71320","MOUSAPP2024","2021SGR-01065","AC19/00129","2021SGR-00789","PMF2021-IN000681","RED2022\\u2013134191-T","2023-00356","2019\\u201302397","PI18/01843"],"pubmed_authors":["Estrada F","Montalvo I","Sanchez-Gistau V","Labad J","Llaurador-Coll M","Zetterberg H","Benedet AL","Vilella E"],"additional_accession":[]},"is_claimable":false,"name":"Plasma profiles of neurology-related proteins in at-risk mental state and first-episode psychosis: Associations with psychotic symptoms and cognitive performance.","description":"<h4>Background</h4>Early diagnosis of psychosis is crucial, and biomarker detection may provide insights into the pathophysiology of psychosis and the potential for the development of early diagnostic tools. In particular, blood-based proteomic profiling has yielded promising results for psychiatric disorders because of the use of novel high-throughput techniques and the feasibility of performing blood extractions in routine clinical practice.<h4>Study design and methodology</h4>Here, we studied 182 participants (33.3 % females, X‾ <sub>age</sub> = 24.66 ± 5.05), comprising 50 healthy controls (HCs), 37 patients with an at-risk mental state (ARMS) and 95 patients with a first episode of psychosis (FEP). We used a panel of 92 neurology-related proteins in a multiplex immunoassay to identify","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-14T04:55:08.75Z","creation":"2026-06-14T03:08:41.892Z"},"accession":"S-EPMC12648619","cross_references":{"pubmed":["41311686"],"doi":["10.1016/j.bbih.2025.101134"]}}