biostudies-literatureLlaurador-Coll MGeneralitat de CatalunyaCarlos III Health InstituteEuropean Innovation CouncilStiftelsen för Gamla TjänarinnorRovira i Virgili UniversityMinisterio de Ciencia e InnovaciónSwedish Research CouncilAlzheimer&apos;s AssociationAlzheimer FundGobierno de Espana Ministerio de Ciencia e InnovacionEuropean Regional Development FundGovernment of Catalonia Agency for Administration of University and Research Grants101134https://www.ebi.ac.uk/biostudies/studies/S-EPMC12648619biostudies-literatureUnknown50<h4>Background</h4>Early diagnosis of psychosis is crucial, and biomarker detection may provide insights into the pathophysiology of psychosis and the potential for the development of early diagnostic tools. In particular, blood-based proteomic profiling has yielded promising results for psychiatric disorders because of the use of novel high-throughput techniques and the feasibility of performing blood extractions in routine clinical practice.<h4>Study design and methodology</h4>Here, we studied 182 participants (33.3 % females, X‾ _age = 24.66 ± 5.05), comprising 50 healthy controls (HCs), 37 patients with an at-risk mental state (ARMS) and 95 patients with a first episode of psychosis (FEP). We used a panel of 92 neurology-related proteins in a multiplex immunoassay to identifyBrain, behavior, & immunity - healthPlasma profiles of neurology-related proteins in at-risk mental state and first-episode psychosis: Associations with psychotic symptoms and cognitive performance.PMC12648619-22-9745642022-01018AF-940262ALFGBG-71320MOUSAPP20242021SGR-01065AC19/001292021SGR-00789PMF2021-IN000681RED2022\u2013134191-T2023-003562019\u201302397PI18/01843Estrada FMontalvo ISanchez-Gistau VLabad JLlaurador-Coll MZetterberg HBenedet ALVilella EfalsePlasma profiles of neurology-related proteins in at-risk mental state and first-episode psychosis: Associations with psychotic symptoms and cognitive performance.<h4>Background</h4>Early diagnosis of psychosis is crucial, and biomarker detection may provide insights into the pathophysiology of psychosis and the potential for the development of early diagnostic tools. In particular, blood-based proteomic profiling has yielded promising results for psychiatric disorders because of the use of novel high-throughput techniques and the feasibility of performing blood extractions in routine clinical practice.<h4>Study design and methodology</h4>Here, we studied 182 participants (33.3 % females, X‾ _age = 24.66 ± 5.05), comprising 50 healthy controls (HCs), 37 patients with an at-risk mental state (ARMS) and 95 patients with a first episode of psychosis (FEP). We used a panel of 92 neurology-related proteins in a multiplex immunoassay to identify2025-01-01T00:00:00Z2025 Dec2026-06-14T04:55:08.75Z2026-06-14T03:08:41.892ZS-EPMC126486194131168610.1016/j.bbih.2025.101134