biostudies-literatureUnknown7(12)Kawtharany HAmerican college of Rheumatology<h4>Objective</h4>To assess the impact of renal replacement therapy in people with lupus nephritis (LN)-associated end-stage kidney disease (ESKD) and support the development of the 2024 American College of Rheumatology LN treatment guidelines.<h4>Methods</h4>We conducted a systematic literature review and meta-analysis to address three Population, Intervention, Comparison, and Outcome (PICO) questions related to renal replacement therapy for ESKD due to LN, including comparisons of kidney transplant versus dialysis, hemodialysis versus peritoneal dialysis, and preemptive kidney transplant versus no preemptive kidney transplant. Outcomes of interest included mortality, cardiovascular (CV) events, infections, lupus flares, disease-related damage, graft failure, and quality of life. We conduACR open rheumatologye70121https://www.ebi.ac.uk/biostudies/studies/S-EPMC12648630biostudies-literatureRenal Replacement Therapy in Lupus Nephritis-Related End-Stage Kidney Disease: A Systematic Review and Meta-Analysis.PMC12648630Jorge AHiraki LTLockwood MMLiang KVIyer PBartels CMSanchez-Rodriguez AKasturi SKawtharany HJohannemann ASSon MBFAzzam MDeQuattro KTurner ASGarg SBermas BLRovin BKirou KALegge AKhawandi JFava AFigueroa-Parra GTurgunbaev MDall'Era MWilliams JNGreco JAskanase ACuellar-Gutierrez MCCunha JSSammaritano LRDuarte-Garcia AMustafa RAfalseRenal Replacement Therapy in Lupus Nephritis-Related End-Stage Kidney Disease: A Systematic Review and Meta-Analysis.<h4>Objective</h4>To assess the impact of renal replacement therapy in people with lupus nephritis (LN)-associated end-stage kidney disease (ESKD) and support the development of the 2024 American College of Rheumatology LN treatment guidelines.<h4>Methods</h4>We conducted a systematic literature review and meta-analysis to address three Population, Intervention, Comparison, and Outcome (PICO) questions related to renal replacement therapy for ESKD due to LN, including comparisons of kidney transplant versus dialysis, hemodialysis versus peritoneal dialysis, and preemptive kidney transplant versus no preemptive kidney transplant. Outcomes of interest included mortality, cardiovascular (CV) events, infections, lupus flares, disease-related damage, graft failure, and quality of life. We condu2025-01-01T00:00:00Z2025 Dec2026-06-05T17:01:55.336Z2026-05-19T03:11:27.321ZS-EPMC126486304129426310.1002/acr2.70121