{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Okamura SM"],"funding":["Japan Society for the Promotion of Science"],"pagination":["1815"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12648907"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(1)"],"pubmed_abstract":["<h4>Background</h4>Photodynamic therapy (PDT) utilizing 5-aminolevulinic acid (5-ALA) as a photosensitizing precursor is an approved treatment modality for several types of cancers. However, the increased generation of antioxidants in cancer cells renders them resistant to PDT. MYCN-amplified neuroblastoma shows increased production of reactive oxygen species (ROS) and relies on the glutathione redox system for ROS detoxification. We tested the effectiveness of combining 6-aminonicotinamide (6-AN), a glucose-6-phosphate dehydrogenase inhibitor that modulates nicotinamide adenine dinucleotide phosphate and glutathione redox balance, with PDT for treating neuroblastoma.<h4>Methods</h4>Cellular protoporphyrin IX (PpIX) accumulation, cell proliferation, morphological changes, induction of cell"],"journal":["BMC cancer"],"pubmed_title":["6-Aminonicotinamide enhances the efficacy of 5-aminolevulinic acid-mediated photodynamic therapy for neuroblastoma."],"pmcid":["PMC12648907"],"funding_grant_id":["21K07191 and 25K11091"],"pubmed_authors":["Chelakkot VS","Nakahata K","Hori H","Okamura SM","Linn Z","Toyoda H","Onishi Y"],"additional_accession":[]},"is_claimable":false,"name":"6-Aminonicotinamide enhances the efficacy of 5-aminolevulinic acid-mediated photodynamic therapy for neuroblastoma.","description":"<h4>Background</h4>Photodynamic therapy (PDT) utilizing 5-aminolevulinic acid (5-ALA) as a photosensitizing precursor is an approved treatment modality for several types of cancers. However, the increased generation of antioxidants in cancer cells renders them resistant to PDT. MYCN-amplified neuroblastoma shows increased production of reactive oxygen species (ROS) and relies on the glutathione redox system for ROS detoxification. We tested the effectiveness of combining 6-aminonicotinamide (6-AN), a glucose-6-phosphate dehydrogenase inhibitor that modulates nicotinamide adenine dinucleotide phosphate and glutathione redox balance, with PDT for treating neuroblastoma.<h4>Methods</h4>Cellular protoporphyrin IX (PpIX) accumulation, cell proliferation, morphological changes, induction of cell","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-05T17:54:56.259Z","creation":"2026-05-19T03:12:02.826Z"},"accession":"S-EPMC12648907","cross_references":{"pubmed":["41291487"],"doi":["10.1186/s12885-025-15231-4"]}}