{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xiao X"],"funding":["Jilin Provincial Natural Science Foundation","National Natural Science Foundation of China General Program"],"pagination":["1314"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12649525"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(11)"],"pubmed_abstract":["In this study, we constructed an extraction process for bovine lung peptide-1 (BLP-1) derived from bovine lung tissue utilizing single-factor optimization combined with response surface methodology. We systematically analyzed its antioxidant activity, biological safety, and therapeutic mechanisms against alcoholic liver disease (ALD). In vitro experiments demonstrated that BLP-1 exhibits excellent scavenging activity against various free radicals, while exhibiting no significant cytotoxicity or hemolytic activity. In a model of H<sub>2</sub>O<sub>2</sub>-induced oxidative damage in HepG2 cells, BLP-1 significantly alleviated oxidative stress injury by upregulating the activities of intracellular antioxidant enzymes. Animal experiments further confirmed that BLP-1 significantly reduced seru"],"journal":["Antioxidants (Basel, Switzerland)"],"pubmed_title":["Extraction, Purification and Identification of Bovine Lung Peptides and Its Antioxidant Effects on H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt;-Induced HepG2 Cells and Mice with Alcoholic Liver Injury."],"pmcid":["PMC12649525"],"funding_grant_id":["32273058","20220101286JC"],"pubmed_authors":["Su T","Li Y","Fang J","Hao L","Zhang X","Wang D","Xiao X","Zheng S","Lv Q"],"additional_accession":[]},"is_claimable":false,"name":"Extraction, Purification and Identification of Bovine Lung Peptides and Its Antioxidant Effects on H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt;-Induced HepG2 Cells and Mice with Alcoholic Liver Injury.","description":"In this study, we constructed an extraction process for bovine lung peptide-1 (BLP-1) derived from bovine lung tissue utilizing single-factor optimization combined with response surface methodology. We systematically analyzed its antioxidant activity, biological safety, and therapeutic mechanisms against alcoholic liver disease (ALD). In vitro experiments demonstrated that BLP-1 exhibits excellent scavenging activity against various free radicals, while exhibiting no significant cytotoxicity or hemolytic activity. In a model of H<sub>2</sub>O<sub>2</sub>-induced oxidative damage in HepG2 cells, BLP-1 significantly alleviated oxidative stress injury by upregulating the activities of intracellular antioxidant enzymes. Animal experiments further confirmed that BLP-1 significantly reduced seru","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-05-19T03:18:56.709Z","creation":"2026-05-19T03:11:32.916Z"},"accession":"S-EPMC12649525","cross_references":{"pubmed":["41300471"],"doi":["10.3390/antiox14111314"]}}