{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tauber Z"],"funding":["Palacky University Olomouc, Czech republic"],"pagination":["2606"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12650028"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(11)"],"pubmed_abstract":["<b>Background</b>: Hofbauer cells (HBCs) are fetal-origin macrophages in the placental villous stroma that contribute to immune tolerance at the feto-maternal interface. They predominantly display an M2 phenotype, characterized by CD206 expression. <b>Methods</b>: Using immunohistochemistry and morphometric analysis, we quantified HBCs, assessed CD206 intensity and morphology, and evaluated apoptotic body accumulation in placental villi. Comparisons were made among pregnancies complicated by type 1 diabetes mellitus (T1DM), gestational diabetes mellitus (GDM), and normoglycemic controls, as well as between male and female fetuses. <b>Results</b>: Significant effects of maternal diabetes and fetal sex on CD206 intensity were observed ([diagnosis: F = 2773.00, <i>p</i> < 0.0001; sex: F = 12."],"journal":["Biomedicines"],"pubmed_title":["Fetal Sex Modulates Hofbauer Cells' Response to Diabetes in Human Placenta."],"pmcid":["PMC12650028"],"funding_grant_id":["IGA_LF_2025_001"],"pubmed_authors":["Koubova K","Burianova A","Mrstik M","Cizkova K","Tauber Z"],"additional_accession":[]},"is_claimable":false,"name":"Fetal Sex Modulates Hofbauer Cells' Response to Diabetes in Human Placenta.","description":"<b>Background</b>: Hofbauer cells (HBCs) are fetal-origin macrophages in the placental villous stroma that contribute to immune tolerance at the feto-maternal interface. They predominantly display an M2 phenotype, characterized by CD206 expression. <b>Methods</b>: Using immunohistochemistry and morphometric analysis, we quantified HBCs, assessed CD206 intensity and morphology, and evaluated apoptotic body accumulation in placental villi. Comparisons were made among pregnancies complicated by type 1 diabetes mellitus (T1DM), gestational diabetes mellitus (GDM), and normoglycemic controls, as well as between male and female fetuses. <b>Results</b>: Significant effects of maternal diabetes and fetal sex on CD206 intensity were observed ([diagnosis: F = 2773.00, <i>p</i> < 0.0001; sex: F = 12.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-05-19T03:20:58.781Z","creation":"2026-05-19T03:12:16.694Z"},"accession":"S-EPMC12650028","cross_references":{"pubmed":["41301701"],"doi":["10.3390/biomedicines13112606"]}}