{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li S"],"funding":["Faculty Research Grant from Baylor College of Medicine","Roderick D. MacDonald Research Grant"],"pagination":["2682"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12650049"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(11)"],"pubmed_abstract":["<b>Background/Objectives</b>: Acute kidney injury (AKI) is a frequent and serious complication following left ventricular assist device (LVAD) implantation. This study aimed to predict AKI within 90 days post-LVAD by evaluating urinary levels of vitamin D binding protein (VDBP) and kidney injury molecule-1 (KIM-1). <b>Methods</b>: We prospectively enrolled 29 advanced heart failure patients undergoing LVAD implantation and categorized them into four groups based on pre-LVAD kidney function and hemodynamic stability. Early-morning urine samples were collected 24 h before and 1 week after surgery. Urinary VDBP and KIM-1 levels, normalized to creatinine, were measured. <b>Results</b>: Thirteen patients developed AKI postoperatively. Both biomarkers were significantly elevated in patients with"],"journal":["Biomedicines"],"pubmed_title":["Urinary Vitamin D Binding Protein and Kidney Injury Molecule-1 Are Potent Predictors of Acute Kidney Injury After Left Ventricular Assist Device Implantation."],"pmcid":["PMC12650049"],"funding_grant_id":["N/A","22RDM004"],"pubmed_authors":["Gray Z","Li S","Hochman-Mendez C","Liao KK","Shafii AE","Mondal NK","Walther CP","Murrieta-Alvarez I","Nordick KV"],"additional_accession":[]},"is_claimable":false,"name":"Urinary Vitamin D Binding Protein and Kidney Injury Molecule-1 Are Potent Predictors of Acute Kidney Injury After Left Ventricular Assist Device Implantation.","description":"<b>Background/Objectives</b>: Acute kidney injury (AKI) is a frequent and serious complication following left ventricular assist device (LVAD) implantation. This study aimed to predict AKI within 90 days post-LVAD by evaluating urinary levels of vitamin D binding protein (VDBP) and kidney injury molecule-1 (KIM-1). <b>Methods</b>: We prospectively enrolled 29 advanced heart failure patients undergoing LVAD implantation and categorized them into four groups based on pre-LVAD kidney function and hemodynamic stability. Early-morning urine samples were collected 24 h before and 1 week after surgery. Urinary VDBP and KIM-1 levels, normalized to creatinine, were measured. <b>Results</b>: Thirteen patients developed AKI postoperatively. Both biomarkers were significantly elevated in patients with","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-05-19T03:15:54.092Z","creation":"2026-05-19T03:11:14.582Z"},"accession":"S-EPMC12650049","cross_references":{"pubmed":["41301775"],"doi":["10.3390/biomedicines13112682"]}}