biostudies-literatureLi SFaculty Research Grant from Baylor College of MedicineRoderick D. MacDonald Research Grant2682https://www.ebi.ac.uk/biostudies/studies/S-EPMC12650049biostudies-literatureUnknown13(11)<b>Background/Objectives</b>: Acute kidney injury (AKI) is a frequent and serious complication following left ventricular assist device (LVAD) implantation. This study aimed to predict AKI within 90 days post-LVAD by evaluating urinary levels of vitamin D binding protein (VDBP) and kidney injury molecule-1 (KIM-1). <b>Methods</b>: We prospectively enrolled 29 advanced heart failure patients undergoing LVAD implantation and categorized them into four groups based on pre-LVAD kidney function and hemodynamic stability. Early-morning urine samples were collected 24 h before and 1 week after surgery. Urinary VDBP and KIM-1 levels, normalized to creatinine, were measured. <b>Results</b>: Thirteen patients developed AKI postoperatively. Both biomarkers were significantly elevated in patients withBiomedicinesUrinary Vitamin D Binding Protein and Kidney Injury Molecule-1 Are Potent Predictors of Acute Kidney Injury After Left Ventricular Assist Device Implantation.PMC12650049N/A22RDM004Gray ZLi SHochman-Mendez CLiao KKShafii AEMondal NKWalther CPMurrieta-Alvarez INordick KVfalseUrinary Vitamin D Binding Protein and Kidney Injury Molecule-1 Are Potent Predictors of Acute Kidney Injury After Left Ventricular Assist Device Implantation.<b>Background/Objectives</b>: Acute kidney injury (AKI) is a frequent and serious complication following left ventricular assist device (LVAD) implantation. This study aimed to predict AKI within 90 days post-LVAD by evaluating urinary levels of vitamin D binding protein (VDBP) and kidney injury molecule-1 (KIM-1). <b>Methods</b>: We prospectively enrolled 29 advanced heart failure patients undergoing LVAD implantation and categorized them into four groups based on pre-LVAD kidney function and hemodynamic stability. Early-morning urine samples were collected 24 h before and 1 week after surgery. Urinary VDBP and KIM-1 levels, normalized to creatinine, were measured. <b>Results</b>: Thirteen patients developed AKI postoperatively. Both biomarkers were significantly elevated in patients with2025-01-01T00:00:00Z2025 Oct2026-05-19T03:15:54.092Z2026-05-19T03:11:14.582ZS-EPMC126500494130177510.3390/biomedicines13112682