biostudies-literatureAdero JThe Genomic Tools for Sweetpotato Improvement (GT4SP) project funded by the BMGF provided additional funds for the research1541https://www.ebi.ac.uk/biostudies/studies/S-EPMC12650080biostudies-literatureUnknown14(11)Sweetpotato (<i>Ipomoea batatas</i> L. Lam) production is threatened by complex viral diseases, notably sweet potato virus disease (SPVD) worldwide, which results from co-infection by <i>sweet potato feathery mottle virus</i> (SPFMV) and <i>sweet potato chlorotic stunt virus</i> (SPCSV). This study provides virus-specific transcriptomic insights into the immune responses of three sweetpotato cultivars, 'Beauregard', 'Tanzania', and 'New Kawogo', to SPFMV, SPCSV, and SPVD. Using RNA-seq profiling across three timepoints post-infection at 3, 6, and 12 weeks, we identified distinct virus- and genotype-specific gene expression responses. 'New Kawogo' activated early and sustained immune pathways involving redox regulation, transcriptional control, and hormonal signaling in response to both SPCBiologyVirus-Specific Defense Responses in Sweetpotato: Transcriptomic Insights into Resistance and Susceptibility to SPFMV, SPCSV, and SPVD.PMC12650080Contract ID: OPP1052983Aber PPOpiyo SOYada BDube FSegundo FByarugaba DKAdero JMaria DSsali RKitavi MFei ZKreuze JFfalseVirus-Specific Defense Responses in Sweetpotato: Transcriptomic Insights into Resistance and Susceptibility to SPFMV, SPCSV, and SPVD.Sweetpotato (<i>Ipomoea batatas</i> L. Lam) production is threatened by complex viral diseases, notably sweet potato virus disease (SPVD) worldwide, which results from co-infection by <i>sweet potato feathery mottle virus</i> (SPFMV) and <i>sweet potato chlorotic stunt virus</i> (SPCSV). This study provides virus-specific transcriptomic insights into the immune responses of three sweetpotato cultivars, 'Beauregard', 'Tanzania', and 'New Kawogo', to SPFMV, SPCSV, and SPVD. Using RNA-seq profiling across three timepoints post-infection at 3, 6, and 12 weeks, we identified distinct virus- and genotype-specific gene expression responses. 'New Kawogo' activated early and sustained immune pathways involving redox regulation, transcriptional control, and hormonal signaling in response to both SPC2025-01-01T00:00:00Z2025 Nov2026-05-19T03:27:32.101Z2026-05-19T03:12:23.836ZS-EPMC126500804130033410.3390/biology14111541