{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(11)"],"submitter":["Wang Y"],"pubmed_abstract":["Long non-coding RNAs (lncRNAs) are crucial regulators in eukaryotic organisms, yet their roles in filamentous fungi, particularly in environmental adaptation and metabolic changes, remain largely unexplored. Here, we investigated the roles of lncRNAs in salt stress response, morphological differentiation, and metabolic regulation in <i>Eurotium cristatum</i>. Using strand-specific RNA sequencing, we identified lncRNAs in sexual and asexual mycelia of <i>E. cristatum</i> and analyzed their expression profiles. We identified 203 lncRNAs, with 120 significantly differentially expressed (FDR < 0.01; |log<sub>2</sub> (fold change)| ≥ 1) under salt stress, including 57 upregulated and 63 downregulated in the asexual morph compared to the sexual morph. These lncRNAs correlated with physiological "],"journal":["Biology"],"pagination":["1592"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12650143"],"repository":["biostudies-literature"],"pubmed_title":["Identification of LncRNAs Involved in the Salt Stress Responses of &lt;i&gt;Eurotium cristatum&lt;/i&gt; and Functional Analysis of Their Roles in Morphological Differentiation and Metabolic Regulation."],"pmcid":["PMC12650143"],"pubmed_authors":["Liu Z","Hu Z","Dong M","Qing X","Wang Y","Xu Z","Zhang Q"],"additional_accession":[]},"is_claimable":false,"name":"Identification of LncRNAs Involved in the Salt Stress Responses of &lt;i&gt;Eurotium cristatum&lt;/i&gt; and Functional Analysis of Their Roles in Morphological Differentiation and Metabolic Regulation.","description":"Long non-coding RNAs (lncRNAs) are crucial regulators in eukaryotic organisms, yet their roles in filamentous fungi, particularly in environmental adaptation and metabolic changes, remain largely unexplored. Here, we investigated the roles of lncRNAs in salt stress response, morphological differentiation, and metabolic regulation in <i>Eurotium cristatum</i>. Using strand-specific RNA sequencing, we identified lncRNAs in sexual and asexual mycelia of <i>E. cristatum</i> and analyzed their expression profiles. We identified 203 lncRNAs, with 120 significantly differentially expressed (FDR < 0.01; |log<sub>2</sub> (fold change)| ≥ 1) under salt stress, including 57 upregulated and 63 downregulated in the asexual morph compared to the sexual morph. These lncRNAs correlated with physiological ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-05-19T03:15:34.712Z","creation":"2026-05-19T03:11:26.281Z"},"accession":"S-EPMC12650143","cross_references":{"pubmed":["41300381"],"doi":["10.3390/biology14111592"]}}