{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(11)"],"submitter":["Rachel M"],"pubmed_abstract":["<h4>Background/objectives</h4>Treatment of severe traumatic brain injury (TBI) remains a major challenge in neurocritical care. The functional state of the brain largely depends on the applied ventilation strategy. Many patients develop acute respiratory distress syndrome (ARDS), for which lung-protective ventilation is recommended. However, its effect on outcomes in severe TBI remains unclear. This study aimed to assess whether a lung-protective ventilation strategy improves short-term outcomes in patients with severe TBI complicated by ARDS.<h4>Methods</h4>This multicenter retrospective study included patients with severe TBI and ARDS treated in three Ukrainian tertiary hospitals. Lung-protective ventilation was defined as the use of a low tidal volume and moderate positive end-expiratory pressure (PEEP). The primary endpoint was 28-day mortality; secondary endpoints included the Glasgow Coma Scale (GCS) score and intracranial pressure (ICP) on day 28. Univariate and multivariate logistic regression analyses identified factors associated with mortality.<h4>Results</h4>Mortality did not depend on arterial PaO<sub>2</sub> (<i>p</i> = 0.173) but correlated with lower GCS (<i>p</i> < 0.001), reduced PaO<sub>2</sub>/FiO<sub>2</sub> ratio (<i>p</i> < 0.001), higher tidal volume (<i>p</i> < 0.001), and lower PEEP (<i>p</i> < 0.001). Lung-protective ventilation reduced mortality from 78.6% to 31.4%.<h4>Conclusions</h4>Lung-protective ventilation is safe and effective in severe TBI with ARDS, significantly improving short-term survival without compromising cerebral outcomes."],"journal":["Brain sciences"],"pagination":["1151"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12650321"],"repository":["biostudies-literature"],"pubmed_title":["Efficiency of a Protective Mode of Mechanical Ventilation in Patients with Severe Traumatic Brain Injury Complicated by Acute Respiratory Distress Syndrome."],"pmcid":["PMC12650321"],"pubmed_authors":["Yaroslavska S","Dobrorodniy A","Krenov K","Rachel M","Oliynyk O","Mamonowa M"],"additional_accession":[]},"is_claimable":false,"name":"Efficiency of a Protective Mode of Mechanical Ventilation in Patients with Severe Traumatic Brain Injury Complicated by Acute Respiratory Distress Syndrome.","description":"<h4>Background/objectives</h4>Treatment of severe traumatic brain injury (TBI) remains a major challenge in neurocritical care. The functional state of the brain largely depends on the applied ventilation strategy. Many patients develop acute respiratory distress syndrome (ARDS), for which lung-protective ventilation is recommended. However, its effect on outcomes in severe TBI remains unclear. This study aimed to assess whether a lung-protective ventilation strategy improves short-term outcomes in patients with severe TBI complicated by ARDS.<h4>Methods</h4>This multicenter retrospective study included patients with severe TBI and ARDS treated in three Ukrainian tertiary hospitals. Lung-protective ventilation was defined as the use of a low tidal volume and moderate positive end-expiratory pressure (PEEP). The primary endpoint was 28-day mortality; secondary endpoints included the Glasgow Coma Scale (GCS) score and intracranial pressure (ICP) on day 28. Univariate and multivariate logistic regression analyses identified factors associated with mortality.<h4>Results</h4>Mortality did not depend on arterial PaO<sub>2</sub> (<i>p</i> = 0.173) but correlated with lower GCS (<i>p</i> < 0.001), reduced PaO<sub>2</sub>/FiO<sub>2</sub> ratio (<i>p</i> < 0.001), higher tidal volume (<i>p</i> < 0.001), and lower PEEP (<i>p</i> < 0.001). Lung-protective ventilation reduced mortality from 78.6% to 31.4%.<h4>Conclusions</h4>Lung-protective ventilation is safe and effective in severe TBI with ARDS, significantly improving short-term survival without compromising cerebral outcomes.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-05-20T03:17:39.727Z","creation":"2026-05-20T03:13:16.256Z"},"accession":"S-EPMC12650321","cross_references":{"pubmed":["41300159"],"doi":["10.3390/brainsci15111151"]}}