{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li Y"],"funding":["Dutch Digestive Health Fund","Pfizer"],"pagination":["1596"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12650337"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(11)"],"pubmed_abstract":["Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasing in both prevalence and severity, highlighting the need for non-invasive biomarkers to assess disease activity. Extracellular vesicles (EVs), which carry molecular cargo from their cells of origin, hold promise as accessible biomarkers. We performed proteomic profiling of plasma-derived EVs from 70 patients with MASLD to identify protein signatures associated with key histological features (steatosis, metabolic dysfunction-associated steatohepatitis (MASH), and fibrosis). These proteins were subsequently correlated with magnetic resonance (MR)-based liver imaging. Plasma EV protein profile differed between mild (S1) and advanced steatosis (S3). H4C1, OIT3, and ANPEP were elevated in S3, while CCDC25 and KLHL41 we"],"journal":["Biomolecules"],"pubmed_title":["Plasma Extracellular Vesicles Contain Protein Biomarkers for Capturing Stages of Metabolic Dysfunction-Associated Steatotic Liver Disease: A Preliminary Exploratory Study."],"pmcid":["PMC12650337"],"funding_grant_id":["68328655","WO 21-03"],"pubmed_authors":["Wassenaar NPM","Dullaart RPF","Driessen S","Serna-Salas S","Blokzijl H","Zwirs D","Holleboom AG","Li Y","Houttu VAT","Moshage H","Dijk AV","Mak AL","Verheij J","Wolters JC","Son KCV","Doukas M","Witjes JJ"],"additional_accession":[]},"is_claimable":false,"name":"Plasma Extracellular Vesicles Contain Protein Biomarkers for Capturing Stages of Metabolic Dysfunction-Associated Steatotic Liver Disease: A Preliminary Exploratory Study.","description":"Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasing in both prevalence and severity, highlighting the need for non-invasive biomarkers to assess disease activity. Extracellular vesicles (EVs), which carry molecular cargo from their cells of origin, hold promise as accessible biomarkers. We performed proteomic profiling of plasma-derived EVs from 70 patients with MASLD to identify protein signatures associated with key histological features (steatosis, metabolic dysfunction-associated steatohepatitis (MASH), and fibrosis). These proteins were subsequently correlated with magnetic resonance (MR)-based liver imaging. Plasma EV protein profile differed between mild (S1) and advanced steatosis (S3). H4C1, OIT3, and ANPEP were elevated in S3, while CCDC25 and KLHL41 we","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-05-19T03:22:34.394Z","creation":"2026-05-19T03:11:59.883Z"},"accession":"S-EPMC12650337","cross_references":{"pubmed":["41301514"],"doi":["10.3390/biom15111596"]}}