{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nideffer J"],"funding":["NIAID NIH HHS"],"pagination":["eads2957"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12650476"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(106)"],"pubmed_abstract":["Few studies have tracked human CD4<sup>+</sup> T cell clones through repeated infections. We used longitudinal single-cell RNA and T cell receptor (TCR) tracking to study the functional stability and memory potential of CD4<sup>+</sup> T cell clonotypes during repeated <i>Plasmodium falciparum</i> (<i>Pf</i>) infections in Ugandan children and adults. Nearly all clonotypes displayed a strong preference for one of seven CD4<sup>+</sup> subsets. This phenomenon of \"clonal fidelity\" was influenced by clonal expansion, linking T cell polarization and proliferation in vivo. Using clone tracking, we characterized subset-specific activation trajectories and identified antigen-specific clones. Type 1 regulatory T (T<sub>R</sub>1) cells accounted for nearly 90% of <i>Pf</i>-specific CD4<sup>+</sup>"],"journal":["Science immunology"],"pubmed_title":["Clone tracking through repeated malaria identifies high-fidelity memory CD4 T cell responses."],"pmcid":["PMC12650476"],"funding_grant_id":["R01 AI177377","U01 AI150741","T32 AI007328"],"pubmed_authors":["Garcia Romero A","Nansubuga E","Boonrat P","Bach F","Greenhouse B","Lopez L","Mantilla M","Arinaitwe E","Takahashi S","Musinguzi K","Nankya F","Bacchetta R","Haque A","Gerungan C","Ssewanyana I","Yang N","Jagannathan P","Rodriguez-Barraquer I","Camanag K","Nideffer J","Strubbe S","Kamya MR","Cepika AM","Zedi M","Kim S","van der Ploeg K","Borna S","Roncarolo MG","Dorsey G","Nankabirwa JI"],"additional_accession":[]},"is_claimable":false,"name":"Clone tracking through repeated malaria identifies high-fidelity memory CD4 T cell responses.","description":"Few studies have tracked human CD4<sup>+</sup> T cell clones through repeated infections. We used longitudinal single-cell RNA and T cell receptor (TCR) tracking to study the functional stability and memory potential of CD4<sup>+</sup> T cell clonotypes during repeated <i>Plasmodium falciparum</i> (<i>Pf</i>) infections in Ugandan children and adults. Nearly all clonotypes displayed a strong preference for one of seven CD4<sup>+</sup> subsets. This phenomenon of \"clonal fidelity\" was influenced by clonal expansion, linking T cell polarization and proliferation in vivo. Using clone tracking, we characterized subset-specific activation trajectories and identified antigen-specific clones. Type 1 regulatory T (T<sub>R</sub>1) cells accounted for nearly 90% of <i>Pf</i>-specific CD4<sup>+</sup>","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2026-06-05T18:46:51.828Z","creation":"2026-05-20T03:13:42.802Z"},"accession":"S-EPMC12650476","cross_references":{"pubmed":["40279404"],"doi":["10.1126/sciimmunol.ads2957"]}}