biostudies-literatureUnknown12(11)Romeo VM<b>Background:</b> Immersive Virtual Reality (IVR) is gaining increasing relevance in the field of mental health as a tool for therapeutic simulation and embodied experience. However, most existing VR applications are grounded in cognitive-behavioral frameworks, leaving unexplored the integration of symbolic, intersubjective, and unconscious dimensions. Psychoanalysis-particularly its constructs of setting, rêverie, and transference-offers a unique epistemological basis for designing therapeutic environments that engage implicit emotional processes. <b>Aim:</b> This paper aims to develop a conceptual framework for modeling IVR-based therapeutic settings inspired by psychoanalytic theory and enhanced through IoT-enabled biosensing technologies. <b>Methods/Approach:</b> We propose a three-laBioengineering (Basel, Switzerland)1257https://www.ebi.ac.uk/biostudies/studies/S-EPMC12650620biostudies-literatureImmersive Virtual Reality Environments as Psychoanalytic Settings: A Conceptual Framework for Modeling Unconscious Processes Through IoT-Based Bioengineering Interfaces.PMC12650620Romeo VMfalseImmersive Virtual Reality Environments as Psychoanalytic Settings: A Conceptual Framework for Modeling Unconscious Processes Through IoT-Based Bioengineering Interfaces.<b>Background:</b> Immersive Virtual Reality (IVR) is gaining increasing relevance in the field of mental health as a tool for therapeutic simulation and embodied experience. However, most existing VR applications are grounded in cognitive-behavioral frameworks, leaving unexplored the integration of symbolic, intersubjective, and unconscious dimensions. Psychoanalysis-particularly its constructs of setting, rêverie, and transference-offers a unique epistemological basis for designing therapeutic environments that engage implicit emotional processes. <b>Aim:</b> This paper aims to develop a conceptual framework for modeling IVR-based therapeutic settings inspired by psychoanalytic theory and enhanced through IoT-enabled biosensing technologies. <b>Methods/Approach:</b> We propose a three-la2025-01-01T00:00:00Z2025 Nov2026-05-19T03:21:25.741Z2026-05-19T03:11:51.931ZS-EPMC126506204130121310.3390/bioengineering12111257